Hemodynamic profile and cardiac morphometry in normotensive and severe preeclamptic pregnant women

Peby Lestari, Noroyono Wibowo, Edo Alexander

Research output: Contribution to journalArticlepeer-review


Objective: To identify the differences in hemodynamic profile and morphometric changes of maternal heart in normotensive pregnant women and severe preeclampsia. Materials and methods: Cross-sectional study was conducted on 34 pregnant women divided into three groups: normotensive (n = 12), early-onset (n = 11), and the late-onset (n = 11). Subjects were patient from ER and inpatient unit of the Department of Obstetrics and Gynecology, Faculty of Medicine, Sriwijaya University/Dr Mohammad Hoesin Hospital, Palembang, during April–June 2015. Results: CO values of the early onset group was lower (3.4 + 0.27, p < 0.001) with higher SVR (3100.2 + 261.3, p < 0.001) than the other two groups. SVR in preeclamptic group was higher compared to the control, the early onset presenting higher SVR than the late-onset group (3100.2 + 261.3 vs 2217.1 + 407.8, p < 0.001). Cardiac index variables between groups were also different, except in the early onset group and controls (p = 0.045). In blood pressure and MAP variable, we only noticed difference between the early onset group and control (p < 0.001) as well as late-onset group and controls (p < 0.001). LVMi, LVID and LVPWT in control group was lower than the others (p < 0.001; p = 0.049; p = 0.009), but were similar for the early onset and late-onset groups [98.7 (86.5–203) vs 132 (77.7–17.6); 4.7 (0.4) vs 4.8 (0.5); 1.1 (0.7–1.3) vs 1.1 (0.8–1.6)]. RWT was relatively similar across the three arms of the study (p = 0.264). Conclusion: In severe preeclampsia, there are changes in hemodynamic, ventricular morphometry, and left ventricular function, which is more evident in the group of early-onset preeclampsia than late-onset preeclampsia.

Original languageEnglish
Pages (from-to)113-119
Number of pages7
JournalJournal of SAFOG
Issue number2
Publication statusPublished - 1 Mar 2019


  • Cardiac morphometry
  • Early onset PE
  • Hemodynamic profile
  • Late-onset PE
  • Normotensive


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