Abstract
AIM: To compare the effects of Helicobacter pylori (H pylori ) infection on gastropathy between Indonesian and Japanese patients. METHODS: Biopsy specimens were obtained during upper gastrointestinal endoscopy from 167 subjects (125 Indonesians and 42 Japanese) with uninvestigated symptoms of dyspepsia. The specimens were analyzed for the presence of H pylori using urease analysis, histopathology, and cell culture. The grade and activity of gastritis was assessed using the updated Sydney system. RESULTS: The percentages of Indonesian and Japanese patients who were H pylori -positive at the antrum or body of the stomach were similar (68% and 59.5%, respectively; P = 0.316). Of those who were H pylori -positive, more Japanese patients than Indonesian patients had high levels of polymorphonuclear cells (P = 0.001), mononuclear cells (P = 0.013), glandular atrophy (P = 0.000), and intestinal metaplasia (P = 0.011) in both the antrum and body of the stomach. CONCLUSION: The grade of gastritis and prevalence of mucosal atrophy and intestinal metaplasia were higher in Japanese patients. The difference between Indonesian and Japanese patients was significant.
Original language | English |
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Pages (from-to) | 4928-4931 |
Number of pages | 4 |
Journal | World Journal of Gastroenterology |
Volume | 15 |
Issue number | 39 |
DOIs | |
Publication status | Published - 2009 |
Keywords
- Atrophy
- Gastric cancer
- Gastritis
- Helicobacter pylori
- Intestinal metaplasia