Helicobacter pylori infection and gastropathy: A comparison between Indonesian and Japanese patients

Murdani Abdullah, Hiroyuki Ohtsuka, Abdul Aziz Rani, Tadashi Sato, Ari Fahrial Syam, Masayuki A. Fujino

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

AIM: To compare the effects of Helicobacter pylori (H pylori ) infection on gastropathy between Indonesian and Japanese patients. METHODS: Biopsy specimens were obtained during upper gastrointestinal endoscopy from 167 subjects (125 Indonesians and 42 Japanese) with uninvestigated symptoms of dyspepsia. The specimens were analyzed for the presence of H pylori using urease analysis, histopathology, and cell culture. The grade and activity of gastritis was assessed using the updated Sydney system. RESULTS: The percentages of Indonesian and Japanese patients who were H pylori -positive at the antrum or body of the stomach were similar (68% and 59.5%, respectively; P = 0.316). Of those who were H pylori -positive, more Japanese patients than Indonesian patients had high levels of polymorphonuclear cells (P = 0.001), mononuclear cells (P = 0.013), glandular atrophy (P = 0.000), and intestinal metaplasia (P = 0.011) in both the antrum and body of the stomach. CONCLUSION: The grade of gastritis and prevalence of mucosal atrophy and intestinal metaplasia were higher in Japanese patients. The difference between Indonesian and Japanese patients was significant.

Original languageEnglish
Pages (from-to)4928-4931
Number of pages4
JournalWorld Journal of Gastroenterology
Volume15
Issue number39
DOIs
Publication statusPublished - 1 Dec 2009

Keywords

  • Atrophy
  • Gastric cancer
  • Gastritis
  • Helicobacter pylori
  • Intestinal metaplasia

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