TY - JOUR
T1 - Helicobacter pylori in the Indonesian Malay’s descendants might be imported from other ethnicities
AU - Syam, Ari Fahrial
AU - Waskito, Langgeng Agung
AU - Rezkitha, Yudith Annisa Ayu
AU - Simamora, Rentha Monica
AU - Yusuf, Fauzi
AU - Danchi, Kanserina Esthera
AU - Bakry, Ahmad Fuad
AU - Arnelis,
AU - Mulya, Erwin
AU - Siregar, Gontar Alamsyah
AU - Sugihartono, Titong
AU - Maulahela, Hasan
AU - Doohan, Dalla
AU - Miftahussurur, Muhammad
AU - Yamaoka, Yoshio
N1 - Funding Information:
We observed a high H. pylori prevalence among the Bataknese. The Bataknese descend from Austronesians who originated from Taiwan and the Philippines then migrated to North Sumatra via Java/Borneo. They settled mainly around the Great Toba Lake, which provided fresh water to support their agriculture activity []. Our observation confirmed a previous study showing a high prevalence of H. pylori in Bataknese [, ]. Interestingly, we observed low H. pylori prevalence among the Nias ethnic group, which is believed to have the same roots as the Bataknese. Even Bataknese from Medan tended to have a higher prevalence of H, pylori than people from Dolok Sanggul, Bataknese still commonly use boiled water as their primary drinking water source []. The water source is associated with H. pylori infection. This hypothesis was supported by the high H. pylori infection rate in the Japanese, who have drunk well water since before World War II [, ]. Our risk factor analysis among Indonesians from the five largest islands showed similar results []. This interesting distribution suggested that the main source of H. pylori among Bataknese might originate from Great Toba Lake.
Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - Background: Even though the incidence of H. pylori infection among Malays in the Malay Peninsula is low, we observed a high H. pylori prevalence in Sumatra, which is the main residence of Indonesian Malays. H. pylori prevalence among Indonesian Malay descendants was investigated. Results: Using a combination of five tests, 232 recruited participants were tested for H- pylori and participants were considered positive if at least one test positive. The results showed that the overall H. pylori prevalence was 17.2%. Participants were then categorized into Malay (Aceh, Malay, and Minang), Java (Javanese and Sundanese), Nias, and Bataknese groups. The prevalence of H. pylori was very low among the Malay group (2.8%) and no H. pylori was observed among the Aceh. Similarly, no H. pylori was observed among the Java group. However, the prevalence of H. pylori was high among the Bataknese (52.2%) and moderate among the Nias (6.1%). Multilocus sequence typing showed that H. pylori in Indonesian Malays classified as hpEastAsia with a subpopulation of hspMaori, suggesting that the isolated H. pylori were not a specific Malays H. pylori. Conclusions: Even though the ethnic groups live together as a community, we observed an extremely low H. pylori infection rate among Indonesian Malay descendants with no specific Indonesian Malay H. pylori. The results suggest that H. pylori was not originally among these groups and H. pylori was imported from other ethnic groups.
AB - Background: Even though the incidence of H. pylori infection among Malays in the Malay Peninsula is low, we observed a high H. pylori prevalence in Sumatra, which is the main residence of Indonesian Malays. H. pylori prevalence among Indonesian Malay descendants was investigated. Results: Using a combination of five tests, 232 recruited participants were tested for H- pylori and participants were considered positive if at least one test positive. The results showed that the overall H. pylori prevalence was 17.2%. Participants were then categorized into Malay (Aceh, Malay, and Minang), Java (Javanese and Sundanese), Nias, and Bataknese groups. The prevalence of H. pylori was very low among the Malay group (2.8%) and no H. pylori was observed among the Aceh. Similarly, no H. pylori was observed among the Java group. However, the prevalence of H. pylori was high among the Bataknese (52.2%) and moderate among the Nias (6.1%). Multilocus sequence typing showed that H. pylori in Indonesian Malays classified as hpEastAsia with a subpopulation of hspMaori, suggesting that the isolated H. pylori were not a specific Malays H. pylori. Conclusions: Even though the ethnic groups live together as a community, we observed an extremely low H. pylori infection rate among Indonesian Malay descendants with no specific Indonesian Malay H. pylori. The results suggest that H. pylori was not originally among these groups and H. pylori was imported from other ethnic groups.
KW - Epidemiology
KW - Helicobacter pylori
KW - Malays
KW - Population genetics
KW - Prevalence
KW - Sumatra
UR - http://www.scopus.com/inward/record.url?scp=85107355307&partnerID=8YFLogxK
U2 - 10.1186/s13099-021-00432-6
DO - 10.1186/s13099-021-00432-6
M3 - Article
AN - SCOPUS:85107355307
SN - 1757-4749
VL - 13
JO - Gut Pathogens
JF - Gut Pathogens
IS - 1
M1 - 36
ER -
