Haloperidol vs. dexamethasone in lowering postoperative nausea and vomiting and pain in adult after laparoscopy: A randomized, double-blind study

Aldy Heriwardito, Sidharta Kusuma Manggala, Suryo Indah Widhyanti, Lara Aristya

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The incidence of PONV (Postoperative Nausea and Vomiting) and pain are still one of the most common symptoms of post-surgery and prophylaxis to reduce the event is needed. Therefore, we wanted to know the effectiveness of 1 mg intravenous haloperidol compared to 5 mg intravenous dexamethasone to prevent the occurrence of nausea and vomiting and to control pain in adult patients after laparoscopic surgery. Materials and Methods: Eighty subjects (n = 40 for each group) scheduled for laparoscopic-assisted surgery were enrolled in a randomized double-blind clinical trial. One milligram intravenous haloperidol was given one hour before the end of surgery, while 5 mg intravenous dexamethasone was given right after induction. The occurrence of PONV and VAS pain score were recorded. Results: This study showed a significant difference in the incidence of nausea between haloperidol and dexamethasone at 2-6 hours (5% vs 25%, P = 0.012), 6-12 hours (10% vs 24%, P = 0.012), and 12-24 hours (12.5% vs 60%, P 0.001) after laparoscopic surgery. The incidence of vomiting after laparoscopic surgery between two groups was not significantly different (P > 0,05). However, haloperidol group resulted in lower VAS pain score at every postoperative period with statistically significant result. Conclusion: The administration of 1 mg intravenous haloperidol is significantly better than 5 mg intravenous dexamethasone to prevent the occurrence of nausea and to lower the pain, but not significantly different to prevent the incidence of postoperative vomiting in adult patients after laparoscopic surgery.

Original languageEnglish
Pages (from-to)157-161
Number of pages5
JournalBali Journal of Anesthesiology
Volume6
Issue number3
DOIs
Publication statusPublished - 1 Jul 2022

Keywords

  • Dexamethasone
  • haloperidol
  • nausea
  • pain
  • vomiting

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