TY - JOUR
T1 - Hair growth activity and safety test of ethosomal gel ethyl acetate fraction of nothopanax leaves (Nothopanax scutellarium merr.)
AU - Jufri, Mahdi
AU - Amelia, Lili
AU - Munim, Abdul
N1 - Publisher Copyright:
© 2017 The Authors.
PY - 2017
Y1 - 2017
N2 - Objective: The aims of this study were to know the hair growth activity from the ethosomal gel of ethyl acetate fraction compared to the nonethosomal gel of ethyl acetate fraction, as well as its ability to penetrate into the skin and its safety from ethosomal gel testing. Methods: The hair growth activity was measured by three parameters: Hair length, hair thickness, and hair weight. Results: The results obtained are shown that the ethosomal gel with concentration 1% has better hair growth activity rather than the ethosomal gel with concentration 0.5% and the nonethosomal gel but it has similarity to the positive control (minoxidil gel with concentration 2%). In vitro penetration test using Franz diffusion cells shown that the ethosomal gel with concentration 1% has cumulative penetration of quercetin higher than nonethosomal gel, which value was 3.3175±0.02 µgcm−2 for the ethosomal gel with concentration 1%; and 2.7663±0.19 µgcm-2 for the nonethosomal gel with flux values for the ethosomal gel with concentration 1% and the nonethosomal gel, respectively, are 0.4147±0.01 µgcm−2h−1 and 0.3458±0.02 µgcm−2h−1. Conclusion: As for the safety test using hen’s egg test-chorioallantoic membrane (HET- CAM) safety test) have shown that both concentrations 0.5% and 1% of the ethosomal gel can generate mild irritation for topical application.
AB - Objective: The aims of this study were to know the hair growth activity from the ethosomal gel of ethyl acetate fraction compared to the nonethosomal gel of ethyl acetate fraction, as well as its ability to penetrate into the skin and its safety from ethosomal gel testing. Methods: The hair growth activity was measured by three parameters: Hair length, hair thickness, and hair weight. Results: The results obtained are shown that the ethosomal gel with concentration 1% has better hair growth activity rather than the ethosomal gel with concentration 0.5% and the nonethosomal gel but it has similarity to the positive control (minoxidil gel with concentration 2%). In vitro penetration test using Franz diffusion cells shown that the ethosomal gel with concentration 1% has cumulative penetration of quercetin higher than nonethosomal gel, which value was 3.3175±0.02 µgcm−2 for the ethosomal gel with concentration 1%; and 2.7663±0.19 µgcm-2 for the nonethosomal gel with flux values for the ethosomal gel with concentration 1% and the nonethosomal gel, respectively, are 0.4147±0.01 µgcm−2h−1 and 0.3458±0.02 µgcm−2h−1. Conclusion: As for the safety test using hen’s egg test-chorioallantoic membrane (HET- CAM) safety test) have shown that both concentrations 0.5% and 1% of the ethosomal gel can generate mild irritation for topical application.
KW - Ethosome
KW - Franz diffusion cell
KW - Gel
KW - Hair growth
KW - Hen’s egg test-chorioallantoic membrane
KW - Nothopanax scutellarium
UR - http://www.scopus.com/inward/record.url?scp=85026831269&partnerID=8YFLogxK
U2 - 10.22159/ajpcr.2017.v10i8.18866
DO - 10.22159/ajpcr.2017.v10i8.18866
M3 - Article
AN - SCOPUS:85026831269
SN - 0974-2441
VL - 10
SP - 134
EP - 138
JO - Asian Journal of Pharmaceutical and Clinical Research
JF - Asian Journal of Pharmaceutical and Clinical Research
IS - 8
ER -