TY - JOUR
T1 - Gut Microbiota Profiles in Early- And Late-Onset Colorectal Cancer
T2 - A Potential Diagnostic Biomarker in the Future
AU - Abdullah, Murdani
AU - Sukartini, Ninik
AU - Nursyirwan, Saskia Aziza
AU - Pribadi, Rabbinu Rangga
AU - Maulahela, Hasan
AU - Muzellina, Virly Nanda
AU - Wiraatmadja, Agustinus
AU - Renaldi, Kaka
AU - Utari, Amanda Pitarini
N1 - Funding Information:
This study was supported by Hibah Kolaborasi Riset Internasional University of Indonesia 2019 (NKB-1929/UN2.R3.1/HKP.05.00/2019), which was budgeted through Directorate of Research and Community Engagement, University of Indonesia.
Publisher Copyright:
© 2021 S. Karger AG, Basel.
PY - 2021
Y1 - 2021
N2 - Background: Researchers believe the role of gut microbiota dysbiosis in the raised incidence of early-onset colorectal cancer (EOCRC). The development of EOCRC may be associated with microbiota dysbiosis either dependently or independently (combined with other risk factors). Summary: Recently, the rising of incidence and mortality of EOCRC have been noted. Some researchers are looking for risk factors influencing this fact. They hypothesize that it may be because of microbiota dysbiosis. Microbiota dysbiosis has been known to promote cancer development through immunity dysregulation and chronic inflammation. Microbiomes profile in late-onset colorectal cancer (LOCRC) among older patients has been documented, but there is still lack of data about microbial profiles among younger colorectal cancer (CRC) patients. This review tries to explain microbial profiles differences between EOCRC and LOCRC as a potential diagnostic biomarker in the future, and whether microbiota can have a role in EOCRC genesis. Key Messages: Microbiota does vary with age, and EOCRC may be associated with colonization of some specific bacteria. Further studies about gut microbiota profiles in EOCRC and LOCRC may provide a new insight on diagnostic biomarker of CRC.
AB - Background: Researchers believe the role of gut microbiota dysbiosis in the raised incidence of early-onset colorectal cancer (EOCRC). The development of EOCRC may be associated with microbiota dysbiosis either dependently or independently (combined with other risk factors). Summary: Recently, the rising of incidence and mortality of EOCRC have been noted. Some researchers are looking for risk factors influencing this fact. They hypothesize that it may be because of microbiota dysbiosis. Microbiota dysbiosis has been known to promote cancer development through immunity dysregulation and chronic inflammation. Microbiomes profile in late-onset colorectal cancer (LOCRC) among older patients has been documented, but there is still lack of data about microbial profiles among younger colorectal cancer (CRC) patients. This review tries to explain microbial profiles differences between EOCRC and LOCRC as a potential diagnostic biomarker in the future, and whether microbiota can have a role in EOCRC genesis. Key Messages: Microbiota does vary with age, and EOCRC may be associated with colonization of some specific bacteria. Further studies about gut microbiota profiles in EOCRC and LOCRC may provide a new insight on diagnostic biomarker of CRC.
KW - Colorectal cancer
KW - Diagnostic biomarker
KW - Early-onset colorectal cancer
KW - Gut microbiota
KW - Microbiota dysbiosis
UR - http://www.scopus.com/inward/record.url?scp=85114428104&partnerID=8YFLogxK
U2 - 10.1159/000516689
DO - 10.1159/000516689
M3 - Review article
AN - SCOPUS:85114428104
SN - 0012-2823
VL - 102
SP - 823
EP - 832
JO - Digestion
JF - Digestion
IS - 6
ER -
