Green synthesis of dihydropyrimidine based on cinnamaldehyde compound under solvent-free using graphene oxide as catalyst

A. H. Cahyana, A. R. Liandi, R. T. Yunarti, D. Febriantini, B. Ardiansah

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Cinnamaldehyde is an essential compound in the cinnamon that have plentiful bioactivities. This research aims to modify cinnamaldehyde to become derivatives of dihydropyrimidine using graphene oxide (GO) as catalyst. GO was synthesized from graphite powder. Afterward, GO was applied in dihydropyrimidine synthesis with one-pot three-component method without solvent. The Fourier transform infrared (FTIR) spectra has proven the formation of GO (3119 cm-1, 1723 cm-1, 1373 cm-1, and 1076 cm-1). To evaluate the ability of GO as catalyst, one synthesized compound with the name 6-methyl-5-propionyl-4-styryl-3,4-dihydropyrimidin-2(1H)-one was obtained. Then, the synthesized compound was analyzed for its absorbance, functional group, and molecular weight using UV/Vis spectrophotometry, FTIR and GC-MS. The best condition of reaction is with the in condition of catalyst 7.5 %, temperature 100 °C, and reaction time 30 minutes. In this condition, the product yield is 83.7 %.

Original languageEnglish
Title of host publicationProceedings of the 4th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2018
EditorsTerry Mart, Djoko Triyono, Ivandini T. Anggraningrum
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735419155
DOIs
Publication statusPublished - 4 Nov 2019
Event4th International Symposium on Current Progress in Mathematics and Sciences 2018, ISCPMS 2018 - Depok, Indonesia
Duration: 30 Oct 201831 Oct 2018

Publication series

NameAIP Conference Proceedings
Volume2168
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference4th International Symposium on Current Progress in Mathematics and Sciences 2018, ISCPMS 2018
CountryIndonesia
CityDepok
Period30/10/1831/10/18

Keywords

  • Cinnamaldehyde
  • dihydropyrimidine
  • graphene oxide
  • solvent-free

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