TY - JOUR
T1 - Glutathione (GSH) and superoxide dismutase (SOD) levels among junior high school students induced by indoor particulate matter 2.5 (PM2.5) and nitrogen dioxide (NO2) exposure
AU - Wispriyono, Bambang
AU - Jalaludin, Juliana
AU - Kusnoputranto, Haryoto
AU - Pakpahan, Sasnila
AU - Permata Aryati, Gita
AU - Pratama, Satria
AU - Librianty, Nurfanida
AU - Rozaliyani, Anna
AU - Fitriani Taufik, Feni
AU - Novirsa, Randy
N1 - Funding Information:
Acknowledgements: Authors would like to thank the government of DKI Jakarta Province, Education Office of DKI Jakarta Province, teachers, students, and parents for supporting this study. This study was funded by International Research Collaboration Grant 2019 [Hibah Kolaborasi Riset lnternasional Tahun 2019 No. NKB-1 938/UN2.R3.1/HKP.05.00/2019].
Publisher Copyright:
© the Author(s), 2021.
PY - 2021
Y1 - 2021
N2 - Background Indoor air pollution has globally known as the risk factor of acute respiratory infection in young children. The exposure to indoor particulate matter 2.5 (PM2.5) and nitrogen dioxide (NO2) at house or school can be a potential risk to children’s health. This study aimed to examine the association between indoor PM2.5 and NO2 with oxidative stress markers in junior high school students. Design and methods: This study was conducted using a cross sectional study with 75 students collected randomly from four junior high schools in Jakarta. PM2.5 and NO2 were measured in classrooms and school yards. The schools were categorized based on the exposure level of PM2.5 and NO2 in classrooms. Superoxide dismutase (SOD) and reduced glutathione (GSH) were examined from the blood sample. All students were interviewed with questionnaires to determine upper respiratory tract infection, smoking family members, mosquito repellent usage, and dietary supplement consumption. Results: Mean concentration of indoor PM2.5 and NO2 were 0.125±0.036 mg m-3 and 36.37±22.33 μg m-3, respectively. The schools which located near to highway showed lower PM2.5 and higher NO2 level indicated the emission of traffic activity. Mean activity of SOD was 96.36±50.94 U mL-1 and mean concentration of GSH was of 0.62±0.09 μg mL-1. Most of the students reported upper respiratory tract infection history, smoking family member, use mosquito repellent at home, and do not consume dietary supplement. Conclusions: The level of oxidative stress markers and the exposure categories of classroom PM2.5 and NO2 was not significantly different, however there were significant correlation with cigarette smoke and mosquito repellent at home. Nevertheless, the exposure of indoor PM2.5 and NO2 increased the risk of the exposure to cigarette smoke and mosquito repellent at home. Further study on the air pollution at school and home is needed to affirm association towards student’s health and to design strategic control efforts.
AB - Background Indoor air pollution has globally known as the risk factor of acute respiratory infection in young children. The exposure to indoor particulate matter 2.5 (PM2.5) and nitrogen dioxide (NO2) at house or school can be a potential risk to children’s health. This study aimed to examine the association between indoor PM2.5 and NO2 with oxidative stress markers in junior high school students. Design and methods: This study was conducted using a cross sectional study with 75 students collected randomly from four junior high schools in Jakarta. PM2.5 and NO2 were measured in classrooms and school yards. The schools were categorized based on the exposure level of PM2.5 and NO2 in classrooms. Superoxide dismutase (SOD) and reduced glutathione (GSH) were examined from the blood sample. All students were interviewed with questionnaires to determine upper respiratory tract infection, smoking family members, mosquito repellent usage, and dietary supplement consumption. Results: Mean concentration of indoor PM2.5 and NO2 were 0.125±0.036 mg m-3 and 36.37±22.33 μg m-3, respectively. The schools which located near to highway showed lower PM2.5 and higher NO2 level indicated the emission of traffic activity. Mean activity of SOD was 96.36±50.94 U mL-1 and mean concentration of GSH was of 0.62±0.09 μg mL-1. Most of the students reported upper respiratory tract infection history, smoking family member, use mosquito repellent at home, and do not consume dietary supplement. Conclusions: The level of oxidative stress markers and the exposure categories of classroom PM2.5 and NO2 was not significantly different, however there were significant correlation with cigarette smoke and mosquito repellent at home. Nevertheless, the exposure of indoor PM2.5 and NO2 increased the risk of the exposure to cigarette smoke and mosquito repellent at home. Further study on the air pollution at school and home is needed to affirm association towards student’s health and to design strategic control efforts.
KW - Antioxidant
KW - Indoor air quality
KW - Oxidative stress
KW - Particulate matter
KW - School
UR - http://www.scopus.com/inward/record.url?scp=85130237020&partnerID=8YFLogxK
U2 - 10.4081/jphr.2021.2372
DO - 10.4081/jphr.2021.2372
M3 - Article
AN - SCOPUS:85130237020
SN - 2279-9028
VL - 10
JO - Journal of Public Health Research
JF - Journal of Public Health Research
IS - 4
M1 - 2372
ER -
