TY - GEN
T1 - Glucose-Responsive Pectin Insulin Patch for Diabetes Mellitus
T2 - 6th International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2021
AU - Krisnamurti, Desak Gede Budi
AU - Purwaningsih, Erni H.
AU - Antarianto, Radiana Dhewayani
AU - Louisa, Melva
N1 - Funding Information:
This study was supported by the grant from the Ministry of Education and Culture of Republic of Indonesia PDUPT 2021/Contract No.NKB-114/UN2.RST/HKP.05.00/2021.
Publisher Copyright:
© 2022 American Institute of Physics Inc.. All rights reserved.
PY - 2022/8/16
Y1 - 2022/8/16
N2 - Diabetes mellitus is a chronic disease that occurs because the pancreas does not produce enough insulin and the body cells cannot use the insulin effectively. Type 1 diabetes mellitus requires insulin therapy, whereas in type 2 diabetes mellitus insulin resistance occurs, so additional insulin therapy may or may not be necessary. Problems related to insulin therapy arise from repeated daily injections that cause pain and damage or trauma to the skin. To overcome problems related to insulin therapy, innovative insulin delivery systems have been developed, such as insulin patches. In the present study, scientific data on pectin insulin patch will be reviewed. This review is based on a search of Medline and citation lists of relevant publications. Several in vitro and in vivo studies have found that pectin can deliver insulin through transdermal patches. The application of a pectin-insulin patch can attenuate hyperglycemia in diabetes, attenuate cardiovascular complications, support hemodynamic control, and attenuate diabetes-associated kidney damage. Overall, the results from multiple studies suggest that a pectin-insulin patch may provide a new valuable tool in diabetes mellitus treatment.
AB - Diabetes mellitus is a chronic disease that occurs because the pancreas does not produce enough insulin and the body cells cannot use the insulin effectively. Type 1 diabetes mellitus requires insulin therapy, whereas in type 2 diabetes mellitus insulin resistance occurs, so additional insulin therapy may or may not be necessary. Problems related to insulin therapy arise from repeated daily injections that cause pain and damage or trauma to the skin. To overcome problems related to insulin therapy, innovative insulin delivery systems have been developed, such as insulin patches. In the present study, scientific data on pectin insulin patch will be reviewed. This review is based on a search of Medline and citation lists of relevant publications. Several in vitro and in vivo studies have found that pectin can deliver insulin through transdermal patches. The application of a pectin-insulin patch can attenuate hyperglycemia in diabetes, attenuate cardiovascular complications, support hemodynamic control, and attenuate diabetes-associated kidney damage. Overall, the results from multiple studies suggest that a pectin-insulin patch may provide a new valuable tool in diabetes mellitus treatment.
KW - Diabetes mellitus
KW - Insulin therapy
KW - Pectin-insulin patch
KW - Polymer matrix
KW - Transdermal drug delivery system
UR - http://www.scopus.com/inward/record.url?scp=85138287594&partnerID=8YFLogxK
U2 - 10.1063/5.0098287
DO - 10.1063/5.0098287
M3 - Conference contribution
AN - SCOPUS:85138287594
T3 - AIP Conference Proceedings
BT - 6th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
A2 - Rahman, Siti Fauziyah
A2 - Zakiyuddin, Ahmad
A2 - Whulanza, Yudan
A2 - Intan, Nurul
PB - American Institute of Physics Inc.
Y2 - 7 July 2021 through 8 July 2021
ER -
