TY - JOUR
T1 - Gingival crevicular fluid levels of resistin and adiponectin in chronic periodontitis with type 2 diabetes mellitus
AU - Natalina,
AU - Masulili, Sri Lelyati C.
AU - Harsas, Nadhia Anindhita
AU - Subekti, Imam
AU - Auerkari, Elza Ibrahim
N1 - Funding Information:
All authors have made substantive contribution to this study and/or manuscript, and all have reviewed the final paper prior to its submission. Founding source of this study was from Universitas Indonesia Grand 2015 (Hibah Riset Awal) and no conflicts of interest. The publication of this manuscript is supported by the Directorate of Research and Community Engagement of the Universitas Indonesia.
PY - 2016
Y1 - 2016
N2 - Resistin and adiponectin are adipokines that secreted from adipose tissue that postulated opposing functions in insulin resistance and inflammation. The oral cavity serves as a continuous source of infectious agents that could worsen the diabetic status of the patient and serve as an important risk factor deterioration of diabetes mellitus. The aim of this study was to clarify gingival crevicular fluids (GCF) adipokine levels in chronic periodontitis (CP) suffering type-2 diabetes mellitus (T2DM). Twenty-four subjects with CP (pocket depth ≥5mm), consist of 12 subjects T2DM and 12 subject control NDM (32-65 years old) were selected. The level of resistin and adiponectin was analyzed using ELISA. Resistin level of T2DM compared to NDM was 21.45±10.5 pg/mL and 27.0±13.1 pg/mL respectively. Resistin T2DM was lower than NDM. Adiponectin level T2DM is 20.1±14.9 ng/mL and control group 17.28±6.9 ng/mL. The level of resistin and adiponectin between T2DM and NDM with did not reach statistical significance. Resitin level was lower in T2DM compared to NDM. The adiponectin level was increased in deep pocket.
AB - Resistin and adiponectin are adipokines that secreted from adipose tissue that postulated opposing functions in insulin resistance and inflammation. The oral cavity serves as a continuous source of infectious agents that could worsen the diabetic status of the patient and serve as an important risk factor deterioration of diabetes mellitus. The aim of this study was to clarify gingival crevicular fluids (GCF) adipokine levels in chronic periodontitis (CP) suffering type-2 diabetes mellitus (T2DM). Twenty-four subjects with CP (pocket depth ≥5mm), consist of 12 subjects T2DM and 12 subject control NDM (32-65 years old) were selected. The level of resistin and adiponectin was analyzed using ELISA. Resistin level of T2DM compared to NDM was 21.45±10.5 pg/mL and 27.0±13.1 pg/mL respectively. Resistin T2DM was lower than NDM. Adiponectin level T2DM is 20.1±14.9 ng/mL and control group 17.28±6.9 ng/mL. The level of resistin and adiponectin between T2DM and NDM with did not reach statistical significance. Resitin level was lower in T2DM compared to NDM. The adiponectin level was increased in deep pocket.
KW - Adiponectin
KW - Chronic periodontitis
KW - Gingival crevicular fluids
KW - Resistin
KW - Type-2 diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=85013152286&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85013152286
SN - 1309-100X
VL - 9
SP - 329
EP - 333
JO - Journal of International Dental and Medical Research
JF - Journal of International Dental and Medical Research
IS - Specialissue
ER -