Genotype distribution of T cell receptor β gene in Indonesian nasopharyngeal carcinoma patients

Yurnadi, Purnomo Soeharso, Dwi Anita Suryandari, Nukman Helwi Moeloek, R. Susworo

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Nasopharyngeal carcinoma (NPC) is a multifactorial genetic disease, characteristically endemic and shows considerable differences in its geographical distribution. Besides infection with EBV, genetic factors such as polymorphisms of TCR-β gene contribute to the incidence of NPC. This study investigates the association of TCR-β gene polymorphisms with individual susceptibility to develop NPC in Indonesian ethnic groups. Methods: The study was carried out by the PCR-RFLP method using Bgl II restriction enzyme to digest TCR-β gene. The PCR-RFLP analysis of TCR-β gene was used to determine allotypes of TCR-β gene in NPC patients and control among ethnic Chinese and indigenous groups in the population of Indonesia. Results: The results indicate that the distribution of TCR-β gene allotypes between NPC patients and controls are not significantly different (p > 0.05); however, the frequency of A allele tends to increase in NPC patients. The distribution of TCR-β gene allotypes between Chinese ethnic group was not significantly different from indigenous groups (p > 0.05). Conclusion: The distribution of TCR-β gene allele between NPC group and control groups showed no difference. The distribution of TCR-β gene between ethnic Chinese and indigenous groups showed no difference. Polymorphisms of TCR-β gene are not associated with NPC and ethnic groups in Indonesian population.

Original languageEnglish
Pages (from-to)171-177
Number of pages7
JournalMedical Journal of Indonesia
Volume20
Issue number3
DOIs
Publication statusPublished - 1 Aug 2011

Keywords

  • EBV
  • NPC
  • Polymorphism
  • Susceptibility
  • TCR-ß gene

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