@inproceedings{d3f55223311c4622ac199fc536645d18,
title = "Genotoxicity of NiTi orthodontic wires induced by the release of metal ions",
abstract = "Nowadays with an abundance of wire alloys to choose for orthodontic treatment, dentists must be wise to select an appropriate wire for the treatment while considering its biological effects on the patient. This review will discuss the possible genotoxic effects of NiTi alloy (Nitinol) orthodontic wires caused by metal ion release. Essentially, the release of metal ions promotes ROS production and induces oxidative stress, which will potentially oxidize nucleotide bases and could cause mutations. Even though the release of metal ions cannot be fully avoided, attempts could be made to minimize its effects on the human body. Clinicians should be aware of the patient's relevant status (such as hypersensitivity) and get updated on newer wire alternatives to optimize the patient's treatment while avoiding undesirable biological effects.",
keywords = "genotoxicity, metal ions, nickel-titanium alloy, orthodontic wires, oxidative stress",
author = "Kirana, {Siti Salsabila} and Auerkari, {Elza Ibrahim}",
note = "Funding Information: There are no conflicts of interest. The authors wish to gratefully acknowledge financial support from the Universitad Indonesia to EIA. Publisher Copyright: {\textcopyright} 2021 Author(s).; 5th International Symposium of Biomedical Engineering, ISBE 2020 ; Conference date: 28-07-2020 Through 29-07-2020",
year = "2021",
month = mar,
day = "23",
doi = "10.1063/5.0047255",
language = "English",
series = "AIP Conference Proceedings",
publisher = "American Institute of Physics Inc.",
editor = "Kenny Lischer and Sugeng Supriadi and Rahman, {Siti Fauziyah} and Yudan Whulanza",
booktitle = "5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices",
}