Genotoxicity of NiTi orthodontic wires induced by the release of metal ions

Siti Salsabila Kirana, Elza Ibrahim Auerkari

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Nowadays with an abundance of wire alloys to choose for orthodontic treatment, dentists must be wise to select an appropriate wire for the treatment while considering its biological effects on the patient. This review will discuss the possible genotoxic effects of NiTi alloy (Nitinol) orthodontic wires caused by metal ion release. Essentially, the release of metal ions promotes ROS production and induces oxidative stress, which will potentially oxidize nucleotide bases and could cause mutations. Even though the release of metal ions cannot be fully avoided, attempts could be made to minimize its effects on the human body. Clinicians should be aware of the patient's relevant status (such as hypersensitivity) and get updated on newer wire alternatives to optimize the patient's treatment while avoiding undesirable biological effects.

Original languageEnglish
Title of host publication5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
Subtitle of host publicationProceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020
EditorsKenny Lischer, Sugeng Supriadi, Siti Fauziyah Rahman, Yudan Whulanza
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735440869
DOIs
Publication statusPublished - 23 Mar 2021
Event5th International Symposium of Biomedical Engineering, ISBE 2020 - Depok, Virtual, Indonesia
Duration: 28 Jul 202029 Jul 2020

Publication series

NameAIP Conference Proceedings
Volume2344
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference5th International Symposium of Biomedical Engineering, ISBE 2020
CountryIndonesia
CityDepok, Virtual
Period28/07/2029/07/20

Keywords

  • genotoxicity
  • metal ions
  • nickel-titanium alloy
  • orthodontic wires
  • oxidative stress

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