Genotoxicity and repair capability of DNA following the oral exposure to analgesic drugs: A review

Ken Sekar Langit, Elza Ibrahim Auerkari

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Genotoxicity is a destructive effect from a substance that impairs genetic material in cells. Drugs are substances that can alter the systemic function, including analgesic drugs. Paracetamol, nonsteroidal anti-inflammatory drugs (NSAIDs), and opioids are three basic analgesic drugs that are often used to relieve the pain available in drug stores. Their action mechanism is known to be safe in a therapeutic dose and has a minimum side effect. Every chemical substance affects the cellular level, including DNA. The drugs have a mechanism to affect the cellular and DNA to control the drugs' damage, such as DNA repair. Each drug affects genetic material depend on the dose and time interval of administration.

Original languageEnglish
Title of host publication5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
Subtitle of host publicationProceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020
EditorsKenny Lischer, Sugeng Supriadi, Siti Fauziyah Rahman, Yudan Whulanza
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735440869
DOIs
Publication statusPublished - 23 Mar 2021
Event5th International Symposium of Biomedical Engineering, ISBE 2020 - Depok, Virtual, Indonesia
Duration: 28 Jul 202029 Jul 2020

Publication series

NameAIP Conference Proceedings
Volume2344
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference5th International Symposium of Biomedical Engineering, ISBE 2020
CountryIndonesia
CityDepok, Virtual
Period28/07/2029/07/20

Keywords

  • diclofenac
  • genotoxicity
  • paracetamol
  • repair capability
  • tramadol

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