Biofarma Corp should adopt big data on vaccine and serum development by analyze genomic sequencing using searching any anomaly. As the root problem, it the anomaly searching requires about 1.62 Terabytes data transient as primary data and 301 Gigabytes as secondary data to get analysis from genomic variance. Moreover Biofarma Corp spent 16 hours for one anomaly searching from 3 Terabytes vaccines. This study proposed big data implementation to handle anomaly searching processes by prioritize less time complexity and less spending storage. It was signalized by a research question, 'How big data technology is applied in searching anomalies on genomic data'. It aimed to implement big data system to facilitate large volume and complex data in order to fulfill business process on Biofarma Corp. It adopted framework architecture as brought by Demchenko, Ngo, and Membrey. This study has designed data flow from FASTA and FATQ as sources for anomalies searching processes. This data flow is facilitated in big data system as designed in this research. As main contribution, this research adopted MapReduce framework to run BLAST algorithm with less spending time. As comparison, MapReduce framework can handle 21, 33, and 55 K-Mer in four minutes respectively while 50 minutes were spent without MapReduce.