Genetic variation of at-hook transcription factor (Akna) Rs3748178 is associated with the relapse of graves' disease

Dwi Yanti, Dwi Anita Suryandari, Fatimah Eliana, Luluk Yunaini, Trisia Lusiana Amir

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: As many as 30-60% of patients with Graves' disease (GD) have relapsed after antithyroid withdrawal, which may be caused by genetic variation of susceptibility factors. This study aimed to analyze the genetic variation of AT-hook transcription factor AKNA rs3748178 and its association with relapse in Graves' disease patients. Methods: This research was a case-control study examining 60 DNA samples of GD patients, who were equally allocated into relapse and remission groups. Genetic variation was analyzed with PCR-RFLP. Fisher's exact test was used for statistical analysis and a p-value less than 0.05 was considered significant. Results: The proportion of patients who experienced a relapse with homozygote wild type (n= 27, 90%) was significantly higher (p= 0.015) compared to the heterozygote and homozygote mutant (n=3, 10%). Graves' disease patients with GG genotype were more likely to have a relapse (OR 6.00, 95% CI 1.48-24.3, p= 0.015). The proportion of patients who experienced a relapse with G allotype (95%) was significantly higher (p= 0.004) compared to A allotype (5%). Graves' disease patients with G allotype were more likely to have a relapse (OR 6.33, 95% CI 1.73-23.2, p= 0.004). Conclusions: Genetic variation of AT-hook transcription factor AKNA rs3748178 is associated with relapse in GD patients.

Original languageEnglish
Pages (from-to)295-300
Number of pages6
JournalJournal of Global Pharma Technology
Volume11
Issue number8
Publication statusPublished - 1 Jan 2019

Keywords

  • Genetic variation
  • Graves' disease
  • Recurrence

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