Genetic variation among Dengue Virus that possibly correlate with pathogenesis

Muhareva Raekiansyah, Tjahjani Mirawati Sudiro

Research output: Contribution to journalArticlepeer-review


Dengue disease are reemerging disease and major health concern in tropical and subtropical regions because of the increasing number of patients, expanding endemic areas and increased occurrence of severe clinical manifestation (DHF/DSS) in the last two decades. Despite extensive studies, it is not fully elucidated mechanism by which dengue infection progress to DHF/DSS. Information obtained so far indicates that both host-related factor and virus virulence are involved. Recent studies have shown several structural differences of dengue virus genome between those associated with DF only and those with the potential to cause DHF. That genome differences might be correlated with pathogenesis.

Original languageEnglish
Pages (from-to)190-194
Number of pages5
JournalMedical Journal of Indonesia
Issue number3
Publication statusPublished - 1 Jul 2004


  • Dengue virus
  • Pathogenesis
  • Virulence factor


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