Genetic Variants of Amelogenin and Non-amelogenin Genes and Its Association with Dental Caries

Michael Owen; Elza Ibrahim Auerkari; Ferry Pergamus Gultom

doi:10.1063/5.0098088

Genetic Variants of Amelogenin and Non-amelogenin Genes and Its Association with Dental Caries

Michael Owen, Elza Ibrahim Auerkari, Ferry Pergamus Gultom

Department of Oral Biology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Dental caries is a permanent and infectious chronic disease that breakdowns a tooth in hard tissue. Dental caries is multifactorial, determined by three known factors: host, agent, and environment. The host factor is the enamel itself which is influenced directly by genetic factors. Genes play an important role in the genetic factors, with no exception for contributing to dental caries. Genes involved in the latter are amelogenin and non-amelogenin genes, compositions of matrix protein secreted by ameloblast and functioning as enamel growth. The protein-encoding gene for amelogenin is amelogenin X (AMELX), whereas protein-encoding genes for non-amelogenin are ameloblastin (AMBN) and enamelin (ENAM). The presence of these three genes in polymorphisms or genetic variants will indirectly affect the susceptibility of the host to have dental caries in the outcome. This narrative review objective is to determine the association between polymorphisms of amelogenin (AMELX) and non-amelogenin (AMBN and ENAM) genes and dental caries.

Original language	English
Title of host publication	6th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
Subtitle of host publication	Proceedings of the 6th International Symposium of Biomedical Engineering, ISBE 2021
Editors	Siti Fauziyah Rahman, Ahmad Zakiyuddin, Yudan Whulanza, Nurul Intan
Publisher	American Institute of Physics Inc.
ISBN (Electronic)	9780735443716
DOIs	https://doi.org/10.1063/5.0098088
Publication status	Published - 16 Aug 2022
Event	6th International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2021 - Depok, Virtual, Indonesia Duration: 7 Jul 2021 → 8 Jul 2021

Publication series

Name	AIP Conference Proceedings
Volume	2537
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	6th International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2021
Country/Territory	Indonesia
City	Depok, Virtual
Period	7/07/21 → 8/07/21

Keywords

AMBN
Amelogenin
AMELX
Caries
ENAM
Genetic Variants
Non-amelogenin
Polymorphism

Access to Document

10.1063/5.0098088

Cite this

Owen, M., Auerkari, E. I., & Gultom, F. P. (2022). Genetic Variants of Amelogenin and Non-amelogenin Genes and Its Association with Dental Caries. In S. F. Rahman, A. Zakiyuddin, Y. Whulanza, & N. Intan (Eds.), 6th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the 6th International Symposium of Biomedical Engineering, ISBE 2021 Article 030006 (AIP Conference Proceedings; Vol. 2537). American Institute of Physics Inc.. https://doi.org/10.1063/5.0098088

Owen, Michael ; Auerkari, Elza Ibrahim ; Gultom, Ferry Pergamus. / Genetic Variants of Amelogenin and Non-amelogenin Genes and Its Association with Dental Caries. 6th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the 6th International Symposium of Biomedical Engineering, ISBE 2021. editor / Siti Fauziyah Rahman ; Ahmad Zakiyuddin ; Yudan Whulanza ; Nurul Intan. American Institute of Physics Inc., 2022. (AIP Conference Proceedings).

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title = "Genetic Variants of Amelogenin and Non-amelogenin Genes and Its Association with Dental Caries",

abstract = "Dental caries is a permanent and infectious chronic disease that breakdowns a tooth in hard tissue. Dental caries is multifactorial, determined by three known factors: host, agent, and environment. The host factor is the enamel itself which is influenced directly by genetic factors. Genes play an important role in the genetic factors, with no exception for contributing to dental caries. Genes involved in the latter are amelogenin and non-amelogenin genes, compositions of matrix protein secreted by ameloblast and functioning as enamel growth. The protein-encoding gene for amelogenin is amelogenin X (AMELX), whereas protein-encoding genes for non-amelogenin are ameloblastin (AMBN) and enamelin (ENAM). The presence of these three genes in polymorphisms or genetic variants will indirectly affect the susceptibility of the host to have dental caries in the outcome. This narrative review objective is to determine the association between polymorphisms of amelogenin (AMELX) and non-amelogenin (AMBN and ENAM) genes and dental caries.",

keywords = "AMBN, Amelogenin, AMELX, Caries, ENAM, Genetic Variants, Non-amelogenin, Polymorphism",

author = "Michael Owen and Auerkari, {Elza Ibrahim} and Gultom, {Ferry Pergamus}",

note = "Publisher Copyright: {\textcopyright} 2022 American Institute of Physics Inc.. All rights reserved.; 6th International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2021 ; Conference date: 07-07-2021 Through 08-07-2021",

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language = "English",

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Owen, M, Auerkari, EI & Gultom, FP 2022, Genetic Variants of Amelogenin and Non-amelogenin Genes and Its Association with Dental Caries. in SF Rahman, A Zakiyuddin, Y Whulanza & N Intan (eds), 6th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the 6th International Symposium of Biomedical Engineering, ISBE 2021., 030006, AIP Conference Proceedings, vol. 2537, American Institute of Physics Inc., 6th International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2021, Depok, Virtual, Indonesia, 7/07/21. https://doi.org/10.1063/5.0098088

Genetic Variants of Amelogenin and Non-amelogenin Genes and Its Association with Dental Caries. / Owen, Michael; Auerkari, Elza Ibrahim ; Gultom, Ferry Pergamus.
6th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the 6th International Symposium of Biomedical Engineering, ISBE 2021. ed. / Siti Fauziyah Rahman; Ahmad Zakiyuddin; Yudan Whulanza; Nurul Intan. American Institute of Physics Inc., 2022. 030006 (AIP Conference Proceedings; Vol. 2537).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T1 - Genetic Variants of Amelogenin and Non-amelogenin Genes and Its Association with Dental Caries

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AU - Auerkari, Elza Ibrahim

AU - Gultom, Ferry Pergamus

PY - 2022/8/16

Y1 - 2022/8/16

N2 - Dental caries is a permanent and infectious chronic disease that breakdowns a tooth in hard tissue. Dental caries is multifactorial, determined by three known factors: host, agent, and environment. The host factor is the enamel itself which is influenced directly by genetic factors. Genes play an important role in the genetic factors, with no exception for contributing to dental caries. Genes involved in the latter are amelogenin and non-amelogenin genes, compositions of matrix protein secreted by ameloblast and functioning as enamel growth. The protein-encoding gene for amelogenin is amelogenin X (AMELX), whereas protein-encoding genes for non-amelogenin are ameloblastin (AMBN) and enamelin (ENAM). The presence of these three genes in polymorphisms or genetic variants will indirectly affect the susceptibility of the host to have dental caries in the outcome. This narrative review objective is to determine the association between polymorphisms of amelogenin (AMELX) and non-amelogenin (AMBN and ENAM) genes and dental caries.

AB - Dental caries is a permanent and infectious chronic disease that breakdowns a tooth in hard tissue. Dental caries is multifactorial, determined by three known factors: host, agent, and environment. The host factor is the enamel itself which is influenced directly by genetic factors. Genes play an important role in the genetic factors, with no exception for contributing to dental caries. Genes involved in the latter are amelogenin and non-amelogenin genes, compositions of matrix protein secreted by ameloblast and functioning as enamel growth. The protein-encoding gene for amelogenin is amelogenin X (AMELX), whereas protein-encoding genes for non-amelogenin are ameloblastin (AMBN) and enamelin (ENAM). The presence of these three genes in polymorphisms or genetic variants will indirectly affect the susceptibility of the host to have dental caries in the outcome. This narrative review objective is to determine the association between polymorphisms of amelogenin (AMELX) and non-amelogenin (AMBN and ENAM) genes and dental caries.

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A2 - Rahman, Siti Fauziyah

A2 - Zakiyuddin, Ahmad

A2 - Whulanza, Yudan

A2 - Intan, Nurul

PB - American Institute of Physics Inc.

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Owen M, Auerkari EI , Gultom FP. Genetic Variants of Amelogenin and Non-amelogenin Genes and Its Association with Dental Caries. In Rahman SF, Zakiyuddin A, Whulanza Y, Intan N, editors, 6th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the 6th International Symposium of Biomedical Engineering, ISBE 2021. American Institute of Physics Inc. 2022. 030006. (AIP Conference Proceedings). doi: 10.1063/5.0098088

Genetic Variants of Amelogenin and Non-amelogenin Genes and Its Association with Dental Caries

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Keywords

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