Genetic factors associated with susceptibility to obesity

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This review discusses the various genetic factors and gene products (proteins) related to obesity. The three fundamental mechanisms underlying obesity are: relative increase in energy intake; relative decrease in energy expenditure; and preferential partitioning of ingested calories to fat storage. Gene defects can be related to any one of these mechanisms, either alone or together. Many genetic factors are associated with susceptibility to obesity, i.e. over expression in agouti signaling protein or agouti related proteins; leptin deficiency, leptin receptor mutation or deficiency, abnormality in carboxypeptidase pathway, tubby mutation, over-expression ofGLUT4 glucose transporter, serotonin 5-HT2C receptor mutation, and defect in CCK or CCK-A receptor.

Original languageEnglish
Pages (from-to)222-227
Number of pages6
JournalMedical Journal of Indonesia
Issue number4
Publication statusPublished - 1 Oct 1999


  • Agouti
  • CCK
  • CCK-A receptor
  • Carboxypeptidase
  • GLUT4 glucose transporter
  • Leptin
  • Leptin receptor
  • Serotonin 5-HT2C receptor
  • Tubby


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