Genetic, epigenetic, and environmental influences on dental arch variation

Ferry Pergamus Gultom, Muzdalifah, Fadli Jazaldi, Erlina Hasriati, Elza Ibrahim Auerkari

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Genetics analysis has been used to evaluate the heritability of numerous orofacial traits and features, including malocclusions. The dental arch is an important structure to assess before diagnosing a malocclusion and planning for orthodontic treatment. The eruptive paths of the teeth, jaw development, and dental movement after eruption will contribute to the dental arch details that form under the influence of genetic, epigenetic, and environmental factors. The genetic factors influence the dental arch variation from the early stage of organ development from initiation to terminal differentiation. The dental arch development involves a series of interactions between epithelium and adjacent mesenchymal tissues, mediated by signaling pathways. Disturbances in the interactions will result in abnormalities or variations of dental arch shape and size. Such influence can arise even from single nucleotide polymorphisms (SNPs) associated with the dental arch phenotype. Epigenetic mechanisms can also play a role. For example, some enzymes can change gene expression through histone modifications resulting in phenotypic variation. Furthermore, environmental factors such as unbalanced circum-oral muscular pressure are able to affect dental arch shape and size.

Original languageEnglish
Title of host publication5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
Subtitle of host publicationProceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020
EditorsKenny Lischer, Sugeng Supriadi, Siti Fauziyah Rahman, Yudan Whulanza
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735440869
Publication statusPublished - 23 Mar 2021
Event5th International Symposium of Biomedical Engineering, ISBE 2020 - Depok, Virtual, Indonesia
Duration: 28 Jul 202029 Jul 2020

Publication series

NameAIP Conference Proceedings
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616


Conference5th International Symposium of Biomedical Engineering, ISBE 2020
CityDepok, Virtual


  • circum-oral muscular equilibrium
  • dental arch
  • epigenetic
  • genetic


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