TY - GEN
T1 - Genetic, epigenetic, and environmental influences on dental arch variation
AU - Gultom, Ferry Pergamus
AU - Muzdalifah,
AU - Jazaldi, Fadli
AU - Hasriati, Erlina
AU - Auerkari, Elza Ibrahim
N1 - Funding Information:
Financial support from Universitas Indonesia to EIA is
Publisher Copyright:
© 2021 Author(s).
PY - 2021/3/23
Y1 - 2021/3/23
N2 - Genetics analysis has been used to evaluate the heritability of numerous orofacial traits and features, including malocclusions. The dental arch is an important structure to assess before diagnosing a malocclusion and planning for orthodontic treatment. The eruptive paths of the teeth, jaw development, and dental movement after eruption will contribute to the dental arch details that form under the influence of genetic, epigenetic, and environmental factors. The genetic factors influence the dental arch variation from the early stage of organ development from initiation to terminal differentiation. The dental arch development involves a series of interactions between epithelium and adjacent mesenchymal tissues, mediated by signaling pathways. Disturbances in the interactions will result in abnormalities or variations of dental arch shape and size. Such influence can arise even from single nucleotide polymorphisms (SNPs) associated with the dental arch phenotype. Epigenetic mechanisms can also play a role. For example, some enzymes can change gene expression through histone modifications resulting in phenotypic variation. Furthermore, environmental factors such as unbalanced circum-oral muscular pressure are able to affect dental arch shape and size.
AB - Genetics analysis has been used to evaluate the heritability of numerous orofacial traits and features, including malocclusions. The dental arch is an important structure to assess before diagnosing a malocclusion and planning for orthodontic treatment. The eruptive paths of the teeth, jaw development, and dental movement after eruption will contribute to the dental arch details that form under the influence of genetic, epigenetic, and environmental factors. The genetic factors influence the dental arch variation from the early stage of organ development from initiation to terminal differentiation. The dental arch development involves a series of interactions between epithelium and adjacent mesenchymal tissues, mediated by signaling pathways. Disturbances in the interactions will result in abnormalities or variations of dental arch shape and size. Such influence can arise even from single nucleotide polymorphisms (SNPs) associated with the dental arch phenotype. Epigenetic mechanisms can also play a role. For example, some enzymes can change gene expression through histone modifications resulting in phenotypic variation. Furthermore, environmental factors such as unbalanced circum-oral muscular pressure are able to affect dental arch shape and size.
KW - circum-oral muscular equilibrium
KW - dental arch
KW - epigenetic
KW - genetic
UR - http://www.scopus.com/inward/record.url?scp=85103513846&partnerID=8YFLogxK
U2 - 10.1063/5.0047268
DO - 10.1063/5.0047268
M3 - Conference contribution
AN - SCOPUS:85103513846
T3 - AIP Conference Proceedings
BT - 5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
A2 - Lischer, Kenny
A2 - Supriadi, Sugeng
A2 - Rahman, Siti Fauziyah
A2 - Whulanza, Yudan
PB - American Institute of Physics Inc.
T2 - 5th International Symposium of Biomedical Engineering, ISBE 2020
Y2 - 28 July 2020 through 29 July 2020
ER -