Genetic, epigenetic, and environmental influences on dental arch variation

Ferry Pergamus Gultom; Muzdalifah; Fadli Jazaldi; Erlina Hasriati; Elza Ibrahim Auerkari

doi:10.1063/5.0047268

Genetic, epigenetic, and environmental influences on dental arch variation

Ferry Pergamus Gultom, Muzdalifah, Fadli Jazaldi, Erlina Hasriati, Elza Ibrahim Auerkari

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Citation (Scopus)

Abstract

Genetics analysis has been used to evaluate the heritability of numerous orofacial traits and features, including malocclusions. The dental arch is an important structure to assess before diagnosing a malocclusion and planning for orthodontic treatment. The eruptive paths of the teeth, jaw development, and dental movement after eruption will contribute to the dental arch details that form under the influence of genetic, epigenetic, and environmental factors. The genetic factors influence the dental arch variation from the early stage of organ development from initiation to terminal differentiation. The dental arch development involves a series of interactions between epithelium and adjacent mesenchymal tissues, mediated by signaling pathways. Disturbances in the interactions will result in abnormalities or variations of dental arch shape and size. Such influence can arise even from single nucleotide polymorphisms (SNPs) associated with the dental arch phenotype. Epigenetic mechanisms can also play a role. For example, some enzymes can change gene expression through histone modifications resulting in phenotypic variation. Furthermore, environmental factors such as unbalanced circum-oral muscular pressure are able to affect dental arch shape and size.

Original language	English
Title of host publication	5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
Subtitle of host publication	Proceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020
Editors	Kenny Lischer, Sugeng Supriadi, Siti Fauziyah Rahman, Yudan Whulanza
Publisher	American Institute of Physics Inc.
ISBN (Electronic)	9780735440869
DOIs	https://doi.org/10.1063/5.0047268
Publication status	Published - 23 Mar 2021
Event	5th International Symposium of Biomedical Engineering, ISBE 2020 - Depok, Virtual, Indonesia Duration: 28 Jul 2020 → 29 Jul 2020

Publication series

Name	AIP Conference Proceedings
Volume	2344
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	5th International Symposium of Biomedical Engineering, ISBE 2020
Country/Territory	Indonesia
City	Depok, Virtual
Period	28/07/20 → 29/07/20

Keywords

circum-oral muscular equilibrium
dental arch
epigenetic
genetic

Access to Document

10.1063/5.0047268

Cite this

Gultom, F. P., Muzdalifah, Jazaldi, F., Hasriati, E., & Auerkari, E. I. (2021). Genetic, epigenetic, and environmental influences on dental arch variation. In K. Lischer, S. Supriadi, S. F. Rahman, & Y. Whulanza (Eds.), 5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020 Article 020010 (AIP Conference Proceedings; Vol. 2344). American Institute of Physics Inc.. https://doi.org/10.1063/5.0047268

Gultom, Ferry Pergamus ; Muzdalifah, ; Jazaldi, Fadli et al. / Genetic, epigenetic, and environmental influences on dental arch variation. 5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020. editor / Kenny Lischer ; Sugeng Supriadi ; Siti Fauziyah Rahman ; Yudan Whulanza. American Institute of Physics Inc., 2021. (AIP Conference Proceedings).

@inproceedings{a2d731c04a30488a91dbfc1e0780886e,

title = "Genetic, epigenetic, and environmental influences on dental arch variation",

abstract = "Genetics analysis has been used to evaluate the heritability of numerous orofacial traits and features, including malocclusions. The dental arch is an important structure to assess before diagnosing a malocclusion and planning for orthodontic treatment. The eruptive paths of the teeth, jaw development, and dental movement after eruption will contribute to the dental arch details that form under the influence of genetic, epigenetic, and environmental factors. The genetic factors influence the dental arch variation from the early stage of organ development from initiation to terminal differentiation. The dental arch development involves a series of interactions between epithelium and adjacent mesenchymal tissues, mediated by signaling pathways. Disturbances in the interactions will result in abnormalities or variations of dental arch shape and size. Such influence can arise even from single nucleotide polymorphisms (SNPs) associated with the dental arch phenotype. Epigenetic mechanisms can also play a role. For example, some enzymes can change gene expression through histone modifications resulting in phenotypic variation. Furthermore, environmental factors such as unbalanced circum-oral muscular pressure are able to affect dental arch shape and size.",

keywords = "circum-oral muscular equilibrium, dental arch, epigenetic, genetic",

author = "Gultom, {Ferry Pergamus} and Muzdalifah and Fadli Jazaldi and Erlina Hasriati and Auerkari, {Elza Ibrahim}",

note = "Funding Information: Financial support from Universitas Indonesia to EIA is Publisher Copyright: {\textcopyright} 2021 Author(s).; 5th International Symposium of Biomedical Engineering, ISBE 2020 ; Conference date: 28-07-2020 Through 29-07-2020",

year = "2021",

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publisher = "American Institute of Physics Inc.",

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Gultom, FP, Muzdalifah, , Jazaldi, F, Hasriati, E & Auerkari, EI 2021, Genetic, epigenetic, and environmental influences on dental arch variation. in K Lischer, S Supriadi, SF Rahman & Y Whulanza (eds), 5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020., 020010, AIP Conference Proceedings, vol. 2344, American Institute of Physics Inc., 5th International Symposium of Biomedical Engineering, ISBE 2020, Depok, Virtual, Indonesia, 28/07/20. https://doi.org/10.1063/5.0047268

Genetic, epigenetic, and environmental influences on dental arch variation. / Gultom, Ferry Pergamus; Muzdalifah, ; Jazaldi, Fadli et al.
5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020. ed. / Kenny Lischer; Sugeng Supriadi; Siti Fauziyah Rahman; Yudan Whulanza. American Institute of Physics Inc., 2021. 020010 (AIP Conference Proceedings; Vol. 2344).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Jazaldi, Fadli

AU - Hasriati, Erlina

AU - Auerkari, Elza Ibrahim

PY - 2021/3/23

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N2 - Genetics analysis has been used to evaluate the heritability of numerous orofacial traits and features, including malocclusions. The dental arch is an important structure to assess before diagnosing a malocclusion and planning for orthodontic treatment. The eruptive paths of the teeth, jaw development, and dental movement after eruption will contribute to the dental arch details that form under the influence of genetic, epigenetic, and environmental factors. The genetic factors influence the dental arch variation from the early stage of organ development from initiation to terminal differentiation. The dental arch development involves a series of interactions between epithelium and adjacent mesenchymal tissues, mediated by signaling pathways. Disturbances in the interactions will result in abnormalities or variations of dental arch shape and size. Such influence can arise even from single nucleotide polymorphisms (SNPs) associated with the dental arch phenotype. Epigenetic mechanisms can also play a role. For example, some enzymes can change gene expression through histone modifications resulting in phenotypic variation. Furthermore, environmental factors such as unbalanced circum-oral muscular pressure are able to affect dental arch shape and size.

AB - Genetics analysis has been used to evaluate the heritability of numerous orofacial traits and features, including malocclusions. The dental arch is an important structure to assess before diagnosing a malocclusion and planning for orthodontic treatment. The eruptive paths of the teeth, jaw development, and dental movement after eruption will contribute to the dental arch details that form under the influence of genetic, epigenetic, and environmental factors. The genetic factors influence the dental arch variation from the early stage of organ development from initiation to terminal differentiation. The dental arch development involves a series of interactions between epithelium and adjacent mesenchymal tissues, mediated by signaling pathways. Disturbances in the interactions will result in abnormalities or variations of dental arch shape and size. Such influence can arise even from single nucleotide polymorphisms (SNPs) associated with the dental arch phenotype. Epigenetic mechanisms can also play a role. For example, some enzymes can change gene expression through histone modifications resulting in phenotypic variation. Furthermore, environmental factors such as unbalanced circum-oral muscular pressure are able to affect dental arch shape and size.

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ER -

Gultom FP, Muzdalifah , Jazaldi F, Hasriati E, Auerkari EI. Genetic, epigenetic, and environmental influences on dental arch variation. In Lischer K, Supriadi S, Rahman SF, Whulanza Y, editors, 5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020. American Institute of Physics Inc. 2021. 020010. (AIP Conference Proceedings). doi: 10.1063/5.0047268

Genetic, epigenetic, and environmental influences on dental arch variation

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