Genetic and epigenetic mechanisms in dental caries

Bayu Rachma Gullianne, Ferry Pergamus Gultom, Elza Ibrahim Auerkari

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

There are linkages between genetic factors with dental caries. This caused by the view which regards that environmental factors are more instrumental than genetic factors. Though much research proves that genetic factor have a enough significant role in the occurrence dental caries. Caries is the process that is influenced by many factors, therefore caries are known as multifactorial disease. Definition of caries is a disease on hard tissues of the dental, namely enamel, dentin and cementum are because of interaction from some factors, whom host (teeth), substrate, microorganisms and the role of time. Interaction between microorganisms and carbohydrates (substrate) will result in the atmosphere of acid. With the existence of the atmosphere is sour it then will cause the decline in from dental plaque pH to below 5, this process usually lasts for 3 minutes. The decline in pH in case over and over again will cause a process demineralisasi on dental hard tissues. The process then will continue the damage on organic material in it so that there was dental caries. In the wake of damage organic materials gear, then bacterial invasion occurred and death pulpa tissue followed by the spread of infection on area periapex that causes the pain. One of factor that also serves important in the occurrence of dental caries is teeth (host). The teeth factor can be the form of the shape of tooth anatomy as well as vulnerability this against caries dental. Factor above that associated with genetic factors. The problem that arises next is how large the role of the from genetic factors in caused dental caries.

Original languageEnglish
Title of host publication11th International Seminar on New Paradigm and Innovation on Natural Sciences and Its Application, ISNPINSA 2021
Subtitle of host publicationDeveloping Science and Technology Toward the New Normal Era
EditorsQidir Maulana Binu Soesanto, Damar Nurwahyu Bima, Nor Basid Adiwibawa Prasetya, Heri Sugito, Alik Maulidiyah
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735445116
DOIs
Publication statusPublished - 2 Jun 2023
Event11th International Seminar on New Paradigm and Innovation on Natural Sciences and Its Application: Developing Science and Technology Toward the New Normal Era, ISNPINSA 2021 - Semarang, Virtual, Indonesia
Duration: 14 Oct 202115 Oct 2021

Publication series

NameAIP Conference Proceedings
Volume2738
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference11th International Seminar on New Paradigm and Innovation on Natural Sciences and Its Application: Developing Science and Technology Toward the New Normal Era, ISNPINSA 2021
Country/TerritoryIndonesia
CitySemarang, Virtual
Period14/10/2115/10/21

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