Genetic and epigenetic influence on masseter muscle in the development of skeletal malocclusion

Nisallina Apridini; Nidea Safitri; Fadli Jazaldi; Ferry Pergamus Gultom; Elza Ibrahim Auerkari

doi:10.1063/5.0047262

Genetic and epigenetic influence on masseter muscle in the development of skeletal malocclusion

Nisallina Apridini, Nidea Safitri, Fadli Jazaldi, Ferry Pergamus Gultom, Elza Ibrahim Auerkari

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Masseter muscle is one of the masticatory muscles functioning in mandibular elevation. Its anatomical structure is closely related to the underlying skeletal structure. Thus, changes happened in the muscle structure will affect the growth of the jawbones. Numerical studies have been conducted to demonstrate and correlate the changes in masseter muscle to the skeletal malocclusion. Changes in fiber type properties, genetic, and epigenetic expression of masseter muscle resulting in a significant correlation to specific malocclusion. Single nucleotide polymorphisms (SNPs) is a common type of genetic variation that induced changes in genetic expression of masseter muscle. Nonsense mutation of R577X in ACTN3 gene is one evidence of genetic expression influence on developing skeletal deep-bite malocclusion. While epigenetic mechanism of acetylation and deacetylation promote by acetyltransferase (KAT) and deacetylase (HDAC) will give influence on the transcription of MHC gene.

Original language	English
Title of host publication	5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
Subtitle of host publication	Proceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020
Editors	Kenny Lischer, Sugeng Supriadi, Siti Fauziyah Rahman, Yudan Whulanza
Publisher	American Institute of Physics Inc.
ISBN (Electronic)	9780735440869
DOIs	https://doi.org/10.1063/5.0047262
Publication status	Published - 23 Mar 2021
Event	5th International Symposium of Biomedical Engineering, ISBE 2020 - Depok, Virtual, Indonesia Duration: 28 Jul 2020 → 29 Jul 2020

Publication series

Name	AIP Conference Proceedings
Volume	2344
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	5th International Symposium of Biomedical Engineering, ISBE 2020
Country/Territory	Indonesia
City	Depok, Virtual
Period	28/07/20 → 29/07/20

Keywords

epigenetic
fiber type properties
masseter muscle
skeletal malocclusion
SNPs

Access to Document

10.1063/5.0047262

Cite this

Apridini, N., Safitri, N., Jazaldi, F., Gultom, F. P., & Auerkari, E. I. (2021). Genetic and epigenetic influence on masseter muscle in the development of skeletal malocclusion. In K. Lischer, S. Supriadi, S. F. Rahman, & Y. Whulanza (Eds.), 5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020 [020009] (AIP Conference Proceedings; Vol. 2344). American Institute of Physics Inc.. https://doi.org/10.1063/5.0047262

Apridini, Nisallina ; Safitri, Nidea ; Jazaldi, Fadli et al. / Genetic and epigenetic influence on masseter muscle in the development of skeletal malocclusion. 5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020. editor / Kenny Lischer ; Sugeng Supriadi ; Siti Fauziyah Rahman ; Yudan Whulanza. American Institute of Physics Inc., 2021. (AIP Conference Proceedings).

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title = "Genetic and epigenetic influence on masseter muscle in the development of skeletal malocclusion",

abstract = "Masseter muscle is one of the masticatory muscles functioning in mandibular elevation. Its anatomical structure is closely related to the underlying skeletal structure. Thus, changes happened in the muscle structure will affect the growth of the jawbones. Numerical studies have been conducted to demonstrate and correlate the changes in masseter muscle to the skeletal malocclusion. Changes in fiber type properties, genetic, and epigenetic expression of masseter muscle resulting in a significant correlation to specific malocclusion. Single nucleotide polymorphisms (SNPs) is a common type of genetic variation that induced changes in genetic expression of masseter muscle. Nonsense mutation of R577X in ACTN3 gene is one evidence of genetic expression influence on developing skeletal deep-bite malocclusion. While epigenetic mechanism of acetylation and deacetylation promote by acetyltransferase (KAT) and deacetylase (HDAC) will give influence on the transcription of MHC gene.",

keywords = "epigenetic, fiber type properties, masseter muscle, skeletal malocclusion, SNPs",

author = "Nisallina Apridini and Nidea Safitri and Fadli Jazaldi and Gultom, {Ferry Pergamus} and Auerkari, {Elza Ibrahim}",

note = "Funding Information: There is no conflict of interest. Financial support from Universitas Indonesia to EIA is gratefully appreciated. Publisher Copyright: {\textcopyright} 2021 Author(s).; 5th International Symposium of Biomedical Engineering, ISBE 2020 ; Conference date: 28-07-2020 Through 29-07-2020",

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doi = "10.1063/5.0047262",

language = "English",

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Apridini, N, Safitri, N, Jazaldi, F , Gultom, FP & Auerkari, EI 2021, Genetic and epigenetic influence on masseter muscle in the development of skeletal malocclusion. in K Lischer, S Supriadi, SF Rahman & Y Whulanza (eds), 5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020., 020009, AIP Conference Proceedings, vol. 2344, American Institute of Physics Inc., 5th International Symposium of Biomedical Engineering, ISBE 2020, Depok, Virtual, Indonesia, 28/07/20. https://doi.org/10.1063/5.0047262

Genetic and epigenetic influence on masseter muscle in the development of skeletal malocclusion. / Apridini, Nisallina; Safitri, Nidea; Jazaldi, Fadli et al.

5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020. ed. / Kenny Lischer; Sugeng Supriadi; Siti Fauziyah Rahman; Yudan Whulanza. American Institute of Physics Inc., 2021. 020009 (AIP Conference Proceedings; Vol. 2344).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Safitri, Nidea

AU - Jazaldi, Fadli

AU - Gultom, Ferry Pergamus

AU - Auerkari, Elza Ibrahim

PY - 2021/3/23

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N2 - Masseter muscle is one of the masticatory muscles functioning in mandibular elevation. Its anatomical structure is closely related to the underlying skeletal structure. Thus, changes happened in the muscle structure will affect the growth of the jawbones. Numerical studies have been conducted to demonstrate and correlate the changes in masseter muscle to the skeletal malocclusion. Changes in fiber type properties, genetic, and epigenetic expression of masseter muscle resulting in a significant correlation to specific malocclusion. Single nucleotide polymorphisms (SNPs) is a common type of genetic variation that induced changes in genetic expression of masseter muscle. Nonsense mutation of R577X in ACTN3 gene is one evidence of genetic expression influence on developing skeletal deep-bite malocclusion. While epigenetic mechanism of acetylation and deacetylation promote by acetyltransferase (KAT) and deacetylase (HDAC) will give influence on the transcription of MHC gene.

AB - Masseter muscle is one of the masticatory muscles functioning in mandibular elevation. Its anatomical structure is closely related to the underlying skeletal structure. Thus, changes happened in the muscle structure will affect the growth of the jawbones. Numerical studies have been conducted to demonstrate and correlate the changes in masseter muscle to the skeletal malocclusion. Changes in fiber type properties, genetic, and epigenetic expression of masseter muscle resulting in a significant correlation to specific malocclusion. Single nucleotide polymorphisms (SNPs) is a common type of genetic variation that induced changes in genetic expression of masseter muscle. Nonsense mutation of R577X in ACTN3 gene is one evidence of genetic expression influence on developing skeletal deep-bite malocclusion. While epigenetic mechanism of acetylation and deacetylation promote by acetyltransferase (KAT) and deacetylase (HDAC) will give influence on the transcription of MHC gene.

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Apridini N, Safitri N, Jazaldi F , Gultom FP , Auerkari EI. Genetic and epigenetic influence on masseter muscle in the development of skeletal malocclusion. In Lischer K, Supriadi S, Rahman SF, Whulanza Y, editors, 5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020. American Institute of Physics Inc. 2021. 020009. (AIP Conference Proceedings). doi: 10.1063/5.0047262

Genetic and epigenetic influence on masseter muscle in the development of skeletal malocclusion

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