Genetic and epigenetic aspects of class III malocclusion with mandibular prognathism phenotypes

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Abstract

Malocclusion is a deviation of a normal occlusal relationship, inflicting a notable aesthetic concern and functional hindrance on the affected individuals. Class III malocclusion is a type of malocclusion with several defined phenotypes, such as mandibular prognathism and macrognathia. The early concept of Class III malocclusion is thought to be governed heavily by genetic factors. However, major advancements in research discover that it is somewhat multifactorial, involving the interaction of both genetic and epigenetic factors at some levels. Modern genomic studies on the genetic mechanisms of facial variations show signs of future success in helping to understand the etiology of malocclusion and variation of dentofacial morphology. This knowledge gives helpful insights on the limits of what orthodontic treatments could achieve, which in turn influences orthodontist in diagnosing the severity of Class III malocclusion, choosing the appropriate treatment timing, planning the proper treatment plans, as well as preventing relapse from happening.

Original languageEnglish
Title of host publication5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
Subtitle of host publicationProceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020
EditorsKenny Lischer, Sugeng Supriadi, Siti Fauziyah Rahman, Yudan Whulanza
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735440869
DOIs
Publication statusPublished - 23 Mar 2021
Event5th International Symposium of Biomedical Engineering, ISBE 2020 - Depok, Virtual, Indonesia
Duration: 28 Jul 202029 Jul 2020

Publication series

NameAIP Conference Proceedings
Volume2344
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference5th International Symposium of Biomedical Engineering, ISBE 2020
Country/TerritoryIndonesia
CityDepok, Virtual
Period28/07/2029/07/20

Keywords

  • Class III Malocclusion
  • Epigenetics
  • Genetics
  • Prognahism Phenotype

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