Genetic and epigenetic aspects of class III malocclusion with mandibular prognathism phenotypes

Stephanie Zabrina; Ramadhanti; Fadli Jazaldi; Ferry Pergamus Gultom; Elza Ibrahim Auerkari

doi:10.1063/5.0047282

Genetic and epigenetic aspects of class III malocclusion with mandibular prognathism phenotypes

Stephanie Zabrina, Ramadhanti, Fadli Jazaldi, Ferry Pergamus Gultom, Elza Ibrahim Auerkari

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

5 Citations (Scopus)

Abstract

Malocclusion is a deviation of a normal occlusal relationship, inflicting a notable aesthetic concern and functional hindrance on the affected individuals. Class III malocclusion is a type of malocclusion with several defined phenotypes, such as mandibular prognathism and macrognathia. The early concept of Class III malocclusion is thought to be governed heavily by genetic factors. However, major advancements in research discover that it is somewhat multifactorial, involving the interaction of both genetic and epigenetic factors at some levels. Modern genomic studies on the genetic mechanisms of facial variations show signs of future success in helping to understand the etiology of malocclusion and variation of dentofacial morphology. This knowledge gives helpful insights on the limits of what orthodontic treatments could achieve, which in turn influences orthodontist in diagnosing the severity of Class III malocclusion, choosing the appropriate treatment timing, planning the proper treatment plans, as well as preventing relapse from happening.

Original language	English
Title of host publication	5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
Subtitle of host publication	Proceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020
Editors	Kenny Lischer, Sugeng Supriadi, Siti Fauziyah Rahman, Yudan Whulanza
Publisher	American Institute of Physics Inc.
ISBN (Electronic)	9780735440869
DOIs	https://doi.org/10.1063/5.0047282
Publication status	Published - 23 Mar 2021
Event	5th International Symposium of Biomedical Engineering, ISBE 2020 - Depok, Virtual, Indonesia Duration: 28 Jul 2020 → 29 Jul 2020

Publication series

Name	AIP Conference Proceedings
Volume	2344
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	5th International Symposium of Biomedical Engineering, ISBE 2020
Country/Territory	Indonesia
City	Depok, Virtual
Period	28/07/20 → 29/07/20

Keywords

Class III Malocclusion
Epigenetics
Genetics
Prognahism Phenotype

Access to Document

10.1063/5.0047282

Cite this

Zabrina, S., Ramadhanti, Jazaldi, F., Gultom, F. P., & Auerkari, E. I. (2021). Genetic and epigenetic aspects of class III malocclusion with mandibular prognathism phenotypes. In K. Lischer, S. Supriadi, S. F. Rahman, & Y. Whulanza (Eds.), 5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020 Article 050010 (AIP Conference Proceedings; Vol. 2344). American Institute of Physics Inc.. https://doi.org/10.1063/5.0047282

Zabrina, Stephanie ; Ramadhanti, ; Jazaldi, Fadli et al. / Genetic and epigenetic aspects of class III malocclusion with mandibular prognathism phenotypes. 5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020. editor / Kenny Lischer ; Sugeng Supriadi ; Siti Fauziyah Rahman ; Yudan Whulanza. American Institute of Physics Inc., 2021. (AIP Conference Proceedings).

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title = "Genetic and epigenetic aspects of class III malocclusion with mandibular prognathism phenotypes",

abstract = "Malocclusion is a deviation of a normal occlusal relationship, inflicting a notable aesthetic concern and functional hindrance on the affected individuals. Class III malocclusion is a type of malocclusion with several defined phenotypes, such as mandibular prognathism and macrognathia. The early concept of Class III malocclusion is thought to be governed heavily by genetic factors. However, major advancements in research discover that it is somewhat multifactorial, involving the interaction of both genetic and epigenetic factors at some levels. Modern genomic studies on the genetic mechanisms of facial variations show signs of future success in helping to understand the etiology of malocclusion and variation of dentofacial morphology. This knowledge gives helpful insights on the limits of what orthodontic treatments could achieve, which in turn influences orthodontist in diagnosing the severity of Class III malocclusion, choosing the appropriate treatment timing, planning the proper treatment plans, as well as preventing relapse from happening.",

keywords = "Class III Malocclusion, Epigenetics, Genetics, Prognahism Phenotype",

author = "Stephanie Zabrina and Ramadhanti and Fadli Jazaldi and Gultom, {Ferry Pergamus} and Auerkari, {Elza Ibrahim}",

note = "Funding Information: There is no conflict of interests. Financial support from Universitas Indonesia to EIA is gratefully appreciated. Publisher Copyright: {\textcopyright} 2021 Author(s).; 5th International Symposium of Biomedical Engineering, ISBE 2020 ; Conference date: 28-07-2020 Through 29-07-2020",

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doi = "10.1063/5.0047282",

language = "English",

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publisher = "American Institute of Physics Inc.",

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Zabrina, S, Ramadhanti, , Jazaldi, F, Gultom, FP & Auerkari, EI 2021, Genetic and epigenetic aspects of class III malocclusion with mandibular prognathism phenotypes. in K Lischer, S Supriadi, SF Rahman & Y Whulanza (eds), 5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020., 050010, AIP Conference Proceedings, vol. 2344, American Institute of Physics Inc., 5th International Symposium of Biomedical Engineering, ISBE 2020, Depok, Virtual, Indonesia, 28/07/20. https://doi.org/10.1063/5.0047282

Genetic and epigenetic aspects of class III malocclusion with mandibular prognathism phenotypes. / Zabrina, Stephanie; Ramadhanti, ; Jazaldi, Fadli et al.
5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020. ed. / Kenny Lischer; Sugeng Supriadi; Siti Fauziyah Rahman; Yudan Whulanza. American Institute of Physics Inc., 2021. 050010 (AIP Conference Proceedings; Vol. 2344).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Ramadhanti,

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AU - Gultom, Ferry Pergamus

AU - Auerkari, Elza Ibrahim

PY - 2021/3/23

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N2 - Malocclusion is a deviation of a normal occlusal relationship, inflicting a notable aesthetic concern and functional hindrance on the affected individuals. Class III malocclusion is a type of malocclusion with several defined phenotypes, such as mandibular prognathism and macrognathia. The early concept of Class III malocclusion is thought to be governed heavily by genetic factors. However, major advancements in research discover that it is somewhat multifactorial, involving the interaction of both genetic and epigenetic factors at some levels. Modern genomic studies on the genetic mechanisms of facial variations show signs of future success in helping to understand the etiology of malocclusion and variation of dentofacial morphology. This knowledge gives helpful insights on the limits of what orthodontic treatments could achieve, which in turn influences orthodontist in diagnosing the severity of Class III malocclusion, choosing the appropriate treatment timing, planning the proper treatment plans, as well as preventing relapse from happening.

AB - Malocclusion is a deviation of a normal occlusal relationship, inflicting a notable aesthetic concern and functional hindrance on the affected individuals. Class III malocclusion is a type of malocclusion with several defined phenotypes, such as mandibular prognathism and macrognathia. The early concept of Class III malocclusion is thought to be governed heavily by genetic factors. However, major advancements in research discover that it is somewhat multifactorial, involving the interaction of both genetic and epigenetic factors at some levels. Modern genomic studies on the genetic mechanisms of facial variations show signs of future success in helping to understand the etiology of malocclusion and variation of dentofacial morphology. This knowledge gives helpful insights on the limits of what orthodontic treatments could achieve, which in turn influences orthodontist in diagnosing the severity of Class III malocclusion, choosing the appropriate treatment timing, planning the proper treatment plans, as well as preventing relapse from happening.

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ER -

Zabrina S, Ramadhanti , Jazaldi F, Gultom FP, Auerkari EI. Genetic and epigenetic aspects of class III malocclusion with mandibular prognathism phenotypes. In Lischer K, Supriadi S, Rahman SF, Whulanza Y, editors, 5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020. American Institute of Physics Inc. 2021. 050010. (AIP Conference Proceedings). doi: 10.1063/5.0047282

Genetic and epigenetic aspects of class III malocclusion with mandibular prognathism phenotypes

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