Genes contributing in cleft lip and cleft palate: A literature review

Failure of the palatal shelves with the primary palate or with each other results in cleft palate, with varying degrees of disability. Orofacial clefts are common birth defects of complex etiology involving the interplay of genetic predisposition and enviromental exposures. Both genetic and environmental factors playing an important and influential role.Ethnic and sex differences in the prevalence of orofacial clefting provide further support of a genetic component to these disorders. The researches in genetics subject have shown several genes that cause orofacial cleft, it can be the single gene disorder or aletration of the chromosome.