Congenital hearing loss is caused by factors during pregnancy and delivery. Congenital deafness may affect speech development, social, cognitive, and academic abilities. More problems may arise if no early detection nor intervention are performed.2-4 Hearing loss in infant and children sometimes are followed by mental underdevelopment, emotional problems, and aphasia. Congenital deafness is commonly detected by family members as delayed speech. In current study, polymorphism of S86T was found in all cases (100%). This polymorphism was also found in all cases of Iranian patients including control patients (Hamid et al). According to Lee et al (1992) from uniprot data, amino acid difference in S86T position was called sequence conflict. Etiological diagnosis of hearing impairment is of great importance to ensure early and adequate management. Even after thorough history taking, clinical and audiometric evaluation, the cause of hearing loss remains unclear in a majority of patients.
|Number of pages||8|
|Journal||International Journal of PharmTech Research|
|Publication status||Published - 1 Jan 2015|
- Gap junction beta 2 gene mutation
- Hearing loss
- Indonesian patients
- Non syndromic congenital hearing loss