Background: Autonomic disturbance is one of the common clinical feature in stroke, but there was a small attention attention has been given as to various features of sympathetic dysfunction such as sudomotor dysregulation in cerebrovascular diseases. Although the exact pathogenesis of these disorders is uncertain, it has been suggested that some of these symptoms have commonly been associated with increased activity of the sympathetic nervous system. Sympathetic skin response (SSR) is one of electrophysiology methods to evaluate sympathetic function. Objective: The purpose of the present study was to investigate the features of SSR evoked by electrical nerve stimulation in patients with ischemic stroke. Methods: A cross sectional study was conducted. The target population of this study was all ischemic stroke patients in outpatient clinic Department of Neurology Faculty of Medicine University of Indonesia. We recorded the SSR to electric stimulations in 54 patients with brain infarction. Results: Out of 54 subjects who were enrolled in this study, 61.1% were male, 64.8% between ages 45 – 65 years, 59.3% had an overweight, and 83.3% with hemispheric brain infarction. Abnormal SSR were found in 37 (68.5%) patients, 26 (48.2%) with prolonged latencies and 11 (20.4 %) SSR was absent and bilaterally abnormal SSR were found in 25 (46.3%) patients (21 [38.9%] in hemispheric and 4 [7.4%] in brain stem infarction while unilateral abnormality were found in 12 (22.3%) patients (9 [16.6%] in hemispheric and 3 [5.6%] in brain stem infarction). Conclusions: The study results show that SSR are abnormal in the majority of ischemic stroke patients (68.5%). Abnormalities features were found as prolonged latency and absent of SSR. Most of the SSR abnormalities were bilateral.
|Publication status||Published - 2009|