GAMBARAN FUNGSI KOGNITIF MENGGUNAKAN EVENT RELATED POTENTIAL AUDITORIK PADA PENYANDANG DIABETES MELITUS TIPE 2

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Abstract

Introduction: One of many complications in diabetes mellitus (DM) that was still rare to be discussed is the cognitive dysfunction. The most frequent neurophysiological study being used to screen cognitive dysfunction was the event-related potential (ERP). However, studies about cognitive dysfunction using ERP in type2 DM were few. Method: A cross-sectional study to identify the profile of ranges and means of motor performance, latency, and amplitude of auditory ERP potentials in people with type 2 DM, and the influential factorswas performed in Endocrine Clinic-Internal Medicine Department, Cipto Mangunkusumo Hospital, Jakarta from August to October 2009. Result: Among 68 patients, there were 34 patients (50%) showing prolonged P300 latency. Compared to normal population, the reaction time (440.37 vs. 357 ms) and P300 latency means (345.91 vs. 309.74 ms) was prolonged, and hits rate (95.13 vs. 98%) was lower. Reaction time was influenced by hypertension (p=0.025) and depression (p=0.021) factors. P300 latency was influenced by other DM complications (p=0.038). Female gender (p=0.004; OR 2.86), other chronic DM complications (p=0.005; OR 2.95) and depression (p=0.028; OR 4.92 determined P300 latency abnormality. Conclusion: Female gender, other chronic DM complications, and depression are predictor factors for P300 latency abnormality in type 2 DM patients. ERP study could be used as an objective screening for cognitive dysfunction among people with type 2 DM.
Keywords: Cognitive function, event-related potentials, P300, type 2 DM.
Original languageIndonesian
JournalNeurona
Publication statusPublished - 2010

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