Gambaran ekspresi reseptor estrogen β pada angiofibroma nasofaring belia dengan menggunakan pemeriksaan imunohistokimia

Lenny Anggreani, Marlinda Adham, Zanil Musa, Lisnawati Lisnawati, Saptawati Bardosono

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign hormonal related fibrovascular tumor which originates from superoposterior area of sphenopalatine foramen. Purpose: To determineER-ß expression of JNA patient at Cipto Mangunkusumo Hospital. Method: Descriptive study to determine ß-estrogen receptor (ER-ß) on 27 JNA patients who had been treated at Oncology Division ENT Departement Cipto Mangunkusumo Hospital between 2001-2008 was conducted. Results: ER-ß expression of JNA in this study is 100%. Based on ER-ß staining intensity, 18.5% gave strong intensity, 29.6% with moderate intensity, and 51.9% with weak intensity. According to positive ER-ß cellular, it consist of three groups: less than 25% positive, 25-50% positive, and more than 50% positive, and the result is 3.7%, 3.7%, and 92.6% respectively. Conclusion: Immunohistochemical examination revealed 100% ER-ß expression.
Keywords: Juvenile nasopharyngeal angiofibroma (JNA), ER-ß expression
Original languageEnglish
Pages (from-to)8, 16
JournalOto Rhino Laryngologica Indonesiana
Volume41
Issue number1
DOIs
Publication statusPublished - 2011

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