FUROSEMIDE RESPONSE TO INCREASED NGAL VALUES AS A PREDICTOR OF AKI DEVELOPMENT IN ICU PATIENTS

Background: Response to furosemide (FR) is a parameter that measures the effectiveness of furosemide in increasing urine production. Although the dose of furosemide given varies, FR has proven to be effective as a predictor of progression (AKI), even in patients with high plasma NGAL levels. Objective: To determine the response of furosemide to increasing NGAL values as a predictor of AKI development in ICU patients. Method: Using specific keywords, a comprehensive search for potential articles was conducted on PubMed, Europe PMC, and ClinicalTrials.gov with inclusion criteria for AKI patients treated in the ICU, cohort, case control, and randomized or nonrandomized clinical trial designs, in English which was published from January 2017 to June 2023. Results: Two research results were obtained with a total of 201 patients. It was found that NGAL was able to predict the development of AKI up to stage 3. Furosemide therapy did not have a significant effect on increasing the renal biomarker NGAL (p<0.05). Conclusion: This study concluded that furosemide therapy did not provide a positive or negative response to NGAL, however furosemide administration reduced mortality in AKI patients….