Functional improvement of subcortical aphasia after series of repetitive transcranial magnetic stimulation

Research output: Contribution to journalArticlepeer-review


Background: A re-organization mechanism following such injuries may include overactively recruitment of contralesional homotopic area. Many studies suggest that instead of improvement, this particular mechanism caused supression of functional recovery. Repetitive Transcranial Magnetic Stimulation (rTMS) has been recognized for its effect on inducing long term depression or potentiation in the cortical area. It is now increasingly used as a complementary therapy in aphasia management word widely. Although not widely known, subcortical stroke can caused aphasic syndrome. There is unsufficient data regarding the effects of cortical rTMS on functional changes due to subcortical lesion.
Objective: to study the functional improvement of rTMS subcortical aphasia.
Methods: We observed 5 subcortical chronic post stroke aphasia patients who received 4Hz rTMS (80-90%MT) for 15 minutes, 5 days per week, across 2 weeks, over undamaged Inferior Frontal Gyrus (IFG). On each day of treatment, rTMS were followed by immediately speech therapy session. Fluency, comprehension, naming, repetition, reading, and writing were evaluated before and after the rTMS series completion.
Results: All subjets showed improvement almost in all language modalities. The most significant improved functions were fluency and naming (p<0.05). Great improvements were also seen in reading and written comprehension (p<0.05). Writing skills were also improved eventhough not statistically significant (p >0.05). The least improvement seen were in auditoric comprehension and repetition (p >0.05).
Conclusion: rTMS improved functional outcome language performance of subcortical aphasia. Focal rTMS on the cortex did modify the connected subcortical area.
Original languageEnglish
Pages (from-to)426
JournalBrain Stimulation
Issue number2
Publication statusPublished - 1 Mar 2017


  • subcortical aphasia, stroke, rTMS


Dive into the research topics of 'Functional improvement of subcortical aphasia after series of repetitive transcranial magnetic stimulation'. Together they form a unique fingerprint.

Cite this