TY - JOUR
T1 - Fucoidan cytotoxicity against human breast cancer T47D cell line increases with higher level of sulfate ester group
AU - Saepudin, Endang
AU - Qosthalani, Fildzah Alfita
AU - Sinurat, Ellya
N1 - Publisher Copyright:
© Published under licence by IOP Publishing Ltd.
PY - 2018/2/7
Y1 - 2018/2/7
N2 - The anticancer activity of different sulfate ester group content in different molecular weight was examined. The anticancer activity was achieved in vitro on human breast cancer T47D cell line. Fucoidan with lower molecular weight (5.79 kDa) tends to have lower sulfate ester group content (8.69%) and resulted in higher IC50 value (184.22 μg/mL). While fucoidan with higher molecular weight (785.12 kDa) tends to have higher sulfate level (18.63%) and achieved lower IC50 value (75.69 μg/mL). The result showed that in order to maintain fucoidan cytotoxic activity against human breast cancer T47D cell line, the sulfate content should be remain high. Keywords: fucoidan, sulfate ester group, human breast cancer.
AB - The anticancer activity of different sulfate ester group content in different molecular weight was examined. The anticancer activity was achieved in vitro on human breast cancer T47D cell line. Fucoidan with lower molecular weight (5.79 kDa) tends to have lower sulfate ester group content (8.69%) and resulted in higher IC50 value (184.22 μg/mL). While fucoidan with higher molecular weight (785.12 kDa) tends to have higher sulfate level (18.63%) and achieved lower IC50 value (75.69 μg/mL). The result showed that in order to maintain fucoidan cytotoxic activity against human breast cancer T47D cell line, the sulfate content should be remain high. Keywords: fucoidan, sulfate ester group, human breast cancer.
KW - fucoidan
KW - human breast cancer
KW - sulfate ester group
UR - http://www.scopus.com/inward/record.url?scp=85046286848&partnerID=8YFLogxK
U2 - 10.1088/1757-899X/299/1/012025
DO - 10.1088/1757-899X/299/1/012025
M3 - Conference article
AN - SCOPUS:85046286848
SN - 1757-8981
VL - 299
JO - IOP Conference Series: Materials Science and Engineering
JF - IOP Conference Series: Materials Science and Engineering
IS - 1
M1 - 012025
T2 - 1st International Conference on Chemistry and Material Science, IC2MS 2017
Y2 - 4 November 2017 through 5 November 2017
ER -
