Fucoidan cytotoxicity against human breast cancer T47D cell line increases with higher level of sulfate ester group

Endang Saefudin, Fildzah Alfita Qosthalani, Ellya Sinurat

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1 Citation (Scopus)

Abstract

The anticancer activity of different sulfate ester group content in different molecular weight was examined. The anticancer activity was achieved in vitro on human breast cancer T47D cell line. Fucoidan with lower molecular weight (5.79 kDa) tends to have lower sulfate ester group content (8.69%) and resulted in higher IC50 value (184.22 μg/mL). While fucoidan with higher molecular weight (785.12 kDa) tends to have higher sulfate level (18.63%) and achieved lower IC50 value (75.69 μg/mL). The result showed that in order to maintain fucoidan cytotoxic activity against human breast cancer T47D cell line, the sulfate content should be remain high. Keywords: fucoidan, sulfate ester group, human breast cancer.

Original languageEnglish
Article number012025
JournalIOP Conference Series: Materials Science and Engineering
Volume299
Issue number1
DOIs
Publication statusPublished - 7 Feb 2018
Event1st International Conference on Chemistry and Material Science, IC2MS 2017 - Malang, East Java, Indonesia
Duration: 4 Nov 20175 Nov 2017

Keywords

  • fucoidan
  • human breast cancer
  • sulfate ester group

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