FSH Receptor Gene Polymorphism in Indonesian Women with Polycystic Ovarian Syndrome (PCOS)

Polycystic ovary syndrome (PCOS) is a reproductive problem that often occurs among women in reproductive age, but until now, the etiopathogenesis of PCOS is still unclear. One of the alleles for candidate genes associated with the PCOS incident is the FSH receptor (FSHR) gene. This research was aimed at analyzing the genotypes within Asn680Ser FSHR with PCOS pathogenesis. The total research subject was 142 subjects. DNA isolation was used for performing the RFLP analysis toward Asn680Ser FSHR polymorphism. There was no mean value difference of the genotype distribution within Asn680Ser FSHR between the PCOS and non-PCOS groups (p>0.05). There was no difference of the basal FSHR levels based on the Asn680Ser FSHR genotyping variation between the PCOS and the non-PCOS groups (p >0.05). The Asn680Ser FSHR genotype does not determine the individual susceptibility to suffering from PCOS. There was no difference in basal FSH levels between PCOS and non-PCOS groups based on the Asn680Ser FSHR genotype variation. However, there are differences in the frequency distribution pattern of the FSHR genotype at position 680 in the PCOS group compared to the previous research findings in several countries.