TY - JOUR
T1 - Frailty among HIV-1 Infected Adults under Antiretroviral Therapy in Indonesia
AU - Wulunggono, Wulunggono
AU - Yunihastuti, Evy
AU - Shatri, Hamzah
AU - Wahyudi, Edy Rizal
AU - Ophinni, Youdiil
N1 - Funding Information:
This study was funded by the PITTA grant awarded by the University of Indonesia, Jakarta, Indonesia, grant no. 2074/UN2.R3.1/HKP.05.00/2018.
Publisher Copyright:
© 2019 Bentham Science Publishers.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - BACKGROUND: Increasing age of HIV-1 infected population brought about the risk of frailty as comorbidity, whose prevalence is higher in low and middle-income countries (LMICs). Indonesia as an LMIC also bears a major burden of HIV-1 epidemic with a similarly aging population, but the prevalence of frailty and its predictors are unknown. OBJECTIVES: To identify the prevalence of frailty and analyze its associated factors, among HIV-1 infected adults under antiretroviral therapy in Indonesia. METHODS: A cross-sectional study was conducted among HIV-infected individuals with inclusion criteria of age ≥30 years old and underwent ART for at least 6 months. The main assessment was done using Fried's frailty phenotype score, which categorizes subjects into non-frail, pre-frail, or frail. Factors associated with frailty were characterized and multiple logistic regression analysis was performed. RESULTS: A total of 164 subjects were recruited; male subjects were 118 (72%), the median age was 40.5 years old, and the median CD4 nadir was 53 cells/μl. Frailty was identified among 90 (54.9%) subjects with 84 (51.2%) identified as pre-frail and 6 (3.7%) as frail, with dominant frailty phenotype was weakness in grip strength. The multivariate model showed that depression was the only factor significantly correlated with pre-frailty and frailty (OR 2.14; 95% CI 1.04-4.43, p=0.036). CONCLUSION: Frailty is a common occurrence among HIV-infected patients under ART, with depression as an independent predictive factor.
AB - BACKGROUND: Increasing age of HIV-1 infected population brought about the risk of frailty as comorbidity, whose prevalence is higher in low and middle-income countries (LMICs). Indonesia as an LMIC also bears a major burden of HIV-1 epidemic with a similarly aging population, but the prevalence of frailty and its predictors are unknown. OBJECTIVES: To identify the prevalence of frailty and analyze its associated factors, among HIV-1 infected adults under antiretroviral therapy in Indonesia. METHODS: A cross-sectional study was conducted among HIV-infected individuals with inclusion criteria of age ≥30 years old and underwent ART for at least 6 months. The main assessment was done using Fried's frailty phenotype score, which categorizes subjects into non-frail, pre-frail, or frail. Factors associated with frailty were characterized and multiple logistic regression analysis was performed. RESULTS: A total of 164 subjects were recruited; male subjects were 118 (72%), the median age was 40.5 years old, and the median CD4 nadir was 53 cells/μl. Frailty was identified among 90 (54.9%) subjects with 84 (51.2%) identified as pre-frail and 6 (3.7%) as frail, with dominant frailty phenotype was weakness in grip strength. The multivariate model showed that depression was the only factor significantly correlated with pre-frailty and frailty (OR 2.14; 95% CI 1.04-4.43, p=0.036). CONCLUSION: Frailty is a common occurrence among HIV-infected patients under ART, with depression as an independent predictive factor.
KW - AIDS
KW - antiretroviral therapy
KW - depression
KW - frailty.
KW - HIV-1
KW - LMIC
UR - http://www.scopus.com/inward/record.url?scp=85074673910&partnerID=8YFLogxK
U2 - 10.2174/1570162X17666190828143947
DO - 10.2174/1570162X17666190828143947
M3 - Article
C2 - 31456523
AN - SCOPUS:85074673910
SN - 1570-162X
VL - 17
SP - 204
EP - 213
JO - Current HIV research
JF - Current HIV research
IS - 3
ER -
