Formulation of suspending vehicles for extemporaneous oral liquid compounding with diltiazem hydrochloride as a drug model

Sutriyo, Zahra Meilia Nisa

Research output: Contribution to journalArticle

Abstract

Objective: This study aimed to determine the optimum concentrations of a suspending vehicle and develop a physically and chemically stable formulation containing diltiazem hydrochloride (DTZ). Methods: Stability testing was performed for 30 days in selected suspending vehicle formulas (Formulas A and E). Physical stability tests were performed at room temperature, and physical properties (odor and color) and pH values of suspensions were evaluated. Results: The oral suspensions of DTZ were white and had a drug-like odor, and the pH had significantly decreased during storage. Chemical stability tests of suspensions were performed at room temperature and 4°C±2°C using ultraviolet-visible spectrophotometry. Conclusion: The concentrations of DTZ in oral suspensions fluctuated during the storage period, suggesting that the oral suspensions of DTZ are physically stable but not chemically stable during storage.

Original languageEnglish
Pages (from-to)230-234
Number of pages5
JournalInternational Journal of Applied Pharmaceutics
Volume10
Issue numberSpecial Issue 1
DOIs
Publication statusPublished - 1 Dec 2018

Keywords

  • Diltiazem hydrochloride
  • Extemporaneous oral liquid formulation
  • Stability
  • Suspending vehicle

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