Formulation of orodispersible tablet of luffa acutangula (L) roxb using novel co-processed via spray dried excipient

Rina Adriany, Effionora A, Retnosari Andrajati, M. Hanafi

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Objective: The objective of this research was to co-process via spray dry tablet excipients in the formulation of orodispersible tablet (ODT) containing Luffa acutangula (L) Roxb fruit aqueous extract (LAE) which were prepared by direct compression method. Methods: The excipients and LAE were made by co-process via spray dry to create mixtures that can help in achieving direct compression optimum disintegration time along with the required hardness and friability. The excipients compose by maltodextrin succinate (MDS), polyvinylpyrrolidone (PVP) and mannitol (Mnt) in the ratio (1:1:8; 2:1:7; 3:1:6). The pre-compressive parameters for the blends and post-compressive parameters for the prepared tablets were evaluated. The blend was examined for flowability and compressibility sufficient mechanical integrity. The ODT properties were evaluated for weight variation, hardness, friability, in vitro disintegrating time, and in vitro wetting time. Results: ODT of LAE were prepared using novel co-processed excipients consisting of MDS-PVP-MT (2:1:7) had a shorter disintegration time and showed the best pharmaceutical performance. The formulations showed desired pre and post-compressive characteristics, short term accelerated stability study was performed for optimized formulation and found that LAE ODT were prepared by coprocessed via spray dried no evidence of physical changes. Conclusion: ODT of LAE are successfully prepared using novel MDS-PVP-Mnt (ratio 2:1:7) as excipient by co-processed via spray dried by direct compression method and ODT of LAE would be alternative to the currently available conventional tablets.

Original languageEnglish
Pages (from-to)124-129
Number of pages6
JournalInternational Journal of Pharmacy and Pharmaceutical Sciences
Volume7
Issue number1
Publication statusPublished - 1 Jan 2015

Keywords

  • Co-process spray dried
  • Direct compression
  • Maltodextrinsuccinate
  • Mannitol
  • Orodispersible tablet (ODT)
  • Polyvinylpyrrolidone

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