TY - JOUR
T1 - Formulation of a fast-disintegrating tablet using maltodextrin DE 10-15 and pregelatinizated cassava starch as expedients
AU - Zaki, Ahmad
AU - Anwa, Effionora
AU - Surini, Silvia
N1 - Publisher Copyright:
© 2017 The Authors. Published by Innovare Academic Sciences Pvt Ltd.
PY - 2017/10
Y1 - 2017/10
N2 - Objective: Fast-disintegrating tablets are a pharmaceutical preparation that is rapidly being developed because they can dissolve in the oral cavity without chewing and without additional water support. The type of dissolver is a crucial component in fast-disintegrating tablets. Maltodextrin and pregelatinized cassava starch (PPS) are excipients that can be used as dissolvers. This study aimed to formulate fast-disintegrating tablets using a combination of maltodextrin dextrose equivalent (DE) 10-15 and PPS in various concentrations as excipients. Methods: The cassava starch classified as PPS was obtained. PPS was then mixed with maltodextrin DE 10-15 to create fast-disintegrating tablets using the wet granulation method. Results: Tablet evaluation showed that formula F containing 40% maltodextrin DE 10-15 and 10% PPS was the most effective of the proposed fast-disintegrating tablets. Conclusions: Formula F has a hardness of 3.39 kp, 0.74% friability, a wetting time of 7.87 seconds, and a dissolve time of 38.55 seconds.
AB - Objective: Fast-disintegrating tablets are a pharmaceutical preparation that is rapidly being developed because they can dissolve in the oral cavity without chewing and without additional water support. The type of dissolver is a crucial component in fast-disintegrating tablets. Maltodextrin and pregelatinized cassava starch (PPS) are excipients that can be used as dissolvers. This study aimed to formulate fast-disintegrating tablets using a combination of maltodextrin dextrose equivalent (DE) 10-15 and PPS in various concentrations as excipients. Methods: The cassava starch classified as PPS was obtained. PPS was then mixed with maltodextrin DE 10-15 to create fast-disintegrating tablets using the wet granulation method. Results: Tablet evaluation showed that formula F containing 40% maltodextrin DE 10-15 and 10% PPS was the most effective of the proposed fast-disintegrating tablets. Conclusions: Formula F has a hardness of 3.39 kp, 0.74% friability, a wetting time of 7.87 seconds, and a dissolve time of 38.55 seconds.
KW - Fast-disintegrating tablets
KW - Maltodextrin dextrose equivalent 10-15
KW - Pregelatinized cassava starch
UR - http://www.scopus.com/inward/record.url?scp=85033672848&partnerID=8YFLogxK
U2 - 10.22159/ijap.2017.v9s1.40_46
DO - 10.22159/ijap.2017.v9s1.40_46
M3 - Article
AN - SCOPUS:85033672848
SN - 0975-7058
VL - 9
SP - 71
EP - 73
JO - International Journal of Applied Pharmaceutics
JF - International Journal of Applied Pharmaceutics
ER -