Formulation of a fast-disintegrating tablet using maltodextrin DE 10-15 and pregelatinizated cassava starch as expedients

Ahmad Zaki, Effionora Anwa, Silvia Surini

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: Fast-disintegrating tablets are a pharmaceutical preparation that is rapidly being developed because they can dissolve in the oral cavity without chewing and without additional water support. The type of dissolver is a crucial component in fast-disintegrating tablets. Maltodextrin and pregelatinized cassava starch (PPS) are excipients that can be used as dissolvers. This study aimed to formulate fast-disintegrating tablets using a combination of maltodextrin dextrose equivalent (DE) 10-15 and PPS in various concentrations as excipients. Methods: The cassava starch classified as PPS was obtained. PPS was then mixed with maltodextrin DE 10-15 to create fast-disintegrating tablets using the wet granulation method. Results: Tablet evaluation showed that formula F containing 40% maltodextrin DE 10-15 and 10% PPS was the most effective of the proposed fast-disintegrating tablets. Conclusions: Formula F has a hardness of 3.39 kp, 0.74% friability, a wetting time of 7.87 seconds, and a dissolve time of 38.55 seconds.

Original languageEnglish
Pages (from-to)71-73
Number of pages3
JournalInternational Journal of Applied Pharmaceutics
Volume9
DOIs
Publication statusPublished - 1 Oct 2017

Keywords

  • Fast-disintegrating tablets
  • Maltodextrin dextrose equivalent 10-15
  • Pregelatinized cassava starch

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