Formulation, characterization, and release property of antioxidant supplement capsule with red ginger oleoresin extract-loaded chitosan microparticles

K. Mulia, U. Y. Risqi, I. F. Pane, E. A. Krisanti

Research output: Contribution to journalConference articlepeer-review

2 Citations (Scopus)

Abstract

Ginger is one of the spices that well-known for the health benefit. Ginger containing 6-gingerol and other phenolic compounds that act as antioxidant activity. Bioactive compounds in ginger are sensitive to high temperature, pH, and light so encapsulation is needed for protecting the bioactive compounds from degradation and for controlling the drug release in the gastrointestinal tract. The aim of this study is to get the formulation of the antioxidant supplement capsule containing microparticle chitosan-oleoresin extract from red ginger and excipients that has sustained release in gastrointestinal simulated fluids. Oleoresin extract was obtained by maceration extraction with the yield 6 %, 6-gingerol content of 6 mg/gr dry weight, total phenolic content of 40.6 mg GAE/gr dry weight, and the IC50 DPPH of the oleoresin of 17 ppm. Oleoresin extract, then was encapsulated using chitosan with the encapsulation efficiency is 95.8% and the loading capacity is 4.9%. Hard gelatin capsule was filled with chitosan-oleoresin microparticle, starch as a disintegrant, and magnesium stearate as lubricant. Dissolution test was done by dissolution tester basket method. The release profile shown the burst release in each gastrointestinal simulated fluid. Antioxidant supplement hard gelatin capsule in formula 2 with the composition consisted of 89.5% chitosan-oleoresin microparticle, 10% starch, and 0,5% magnesium stearate show the lowest release in simulated gastric fluid, but the highest release in simulated intestinal fluid. The bioactive compounds in formula 2 can be released in the small intestine.

Original languageEnglish
Article number062008
JournalJournal of Physics: Conference Series
Volume1198
Issue number6
DOIs
Publication statusPublished - 10 May 2019
Event1st Symposium of Emerging Nuclear Technology and Engineering Novelty, SENTEN 2018 - Palembang, South Sumatra, India
Duration: 4 Jul 20185 Jul 2018

Keywords

  • Chitosan microparticles
  • oleoresin extract
  • red ginger
  • release profile
  • supplement capsules

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