Formulation, characterization and in vitro skin penetration of green tea (Camellia sinensis L.) leaves extract-loaded solid lipid nanoparticles

Selvina Dzulhi, Effionora A, Tati Nurhayati

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: This study aims to formulate and evaluate the characteristics and the skin penetration of green tea leaves extract loaded solid lipid nanoparticles (GT-SLN). Methods: GT-SLN was prepared by solvent emulsificationevaporation method. The properties of SLN were characterized by dynamic light scattering (DLS), transmission electron microscopy (TEM), differential scanning calorimetry (DSC), and in vitro penetration studies were investigated with Franz diffusion cells. Results: The GT-SLN1 presented spherical shape with an average particle size of 155.6 ± 10.04 nm; polydispersity index of 0.409 ± 0.05; zeta potential of -30.967 ± 1.29; entrapment efficiency of 81.124 ± 0.443%. In vitro penetration study with Franz diffusion cell showed flux value from GT-SLN1 of 1.965 ± 0.025 μg/cm2.hour and GT 0.261 ± 0.005 μg/cm2.hour. Conclusion: In vitro skin penetration study showed that solid lipid nanoparticles improved the penetration of epigallocatechin gallate (EGCG) through the stratum corneum.

Original languageEnglish
Pages (from-to)57-62
Number of pages6
JournalJournal of Applied Pharmaceutical Science
Volume8
Issue number8
DOIs
Publication statusPublished - 1 Aug 2018

Keywords

  • Camellia sinensis
  • Epigallocatechin gallate (EGCG)
  • Green tea
  • Skin penetration
  • Solid lipid nanoparticle (SLN)
  • Solvent emulsification

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