Formulation and physical stability test of griseofulvin microemulsion gel

Anindya Hana Iradhati, Mahdi Jufri

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: The main objective of this research is to make and evaluate the formulation of a griseofulvin microemulsion gel for topical use to increase the solubility and safety of the drug. Methods: The optimized microemulsion formula contains 5% oleic acid as the oil phase, 25% Tween 80 as the surfactant, and 20% ethanol (96%) as the cosurfactant. Results: Organoleptic observations of the microemulsion showed that it had a clear and transparent yellowish color, while the microemulsion gel had a hazy yellowish color. Both the microemulsion and the microemulsion gel had the smell of alcohol. The size of the globules in the microemulsion and the microemulsion gel was 158.0 nm and 226.0, respectively. Conclusions: The griseofulvin microemulsion gel was stable at 4°C±2°C, 25°C±2°C, and 40°C±2°C.

Original languageEnglish
Pages (from-to)23-26
Number of pages4
JournalInternational Journal of Applied Pharmaceutics
Volume9
DOIs
Publication statusPublished - 1 Oct 2017

Keywords

  • Formulation
  • Griseofulvin
  • Microemulsion gel
  • Physical stability
  • Surfactant

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