Formulation and penetration study of liposome gel xanthone of extract mangosteen pericarp (Garcinia mangostana L.)

The mangosteen pericarp (Garcinia mangostana L.) has been proved rich in compounds of xanthone that have very high potential of antioxidant activity, especially the fractionation of dichloromethane. This study aimed to investigate the in vitro penetration by using liposome xanthone gel dichloromethane fraction of mangosteen pericarp compare non-liposome one and investigate the antioxidant activity. Liposomes were made by thin layer hydration method. The antioxidant activity was determined by DPPH method. Alfa mangostin was determined by TLC densitometry. The IC50 values of dichloromethane fraction are 37.53 ppm. The concentration of α-mangostin in dichloromethane fraction is 49.059 ± 0.8%. The in vitro penetration of α-mangostin of liposome gels had higher penetration (35.33 ± 1.208 μg cm^- hour^-1) than non-liposome gel (8.398 ± 0.018 μg cm^-2hour^-1). Liposome xanthone gel dichloromethane fraction of mangosteen pericarp had better penetration than non-liposome one.