FORMULATION AND DETERMINATION OF QUALITY PARAMETERS OF PROPOLIS EXTRACT MICROCAPSULE TABLETS FROM TETRAGONULA SAPIENS

Diah Kartika Pratami; Deni Rahmat; Rizka Noor Amalia; Heri Hermasnyah; Misri Gozan; Muhamad Sahlan

doi:10.22159/ijap.2022.v14s1.10

FORMULATION AND DETERMINATION OF QUALITY PARAMETERS OF PROPOLIS EXTRACT MICROCAPSULE TABLETS FROM TETRAGONULA SAPIENS

Diah Kartika Pratami, Deni Rahmat, Rizka Noor Amalia, Heri Hermasnyah, Misri Gozan, Muhamad Sahlan

Department of Chemical Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: The study aimed to develop the dry powder of propolis microcapsules into tablet preparations. Methods: The tablet preparation was developed by direct compression method using Avicel PH 102 (filler-binder-disintegrant) with variations in Avicel PH 102 concentration of 50%, 75%, and 100%, respectively. Each of the tablets from these formulations was determined by the quality parameters of the preparation. Results: The results showed that the dry powder microcapsules had a yellow-brown powder physical form, flow time of 0.413g/second, compressibility of 18.56%, and fine powder was 80.04%. Out of the three formulae produced, formula III was the best with a tablet diameter of 11.11±0.01 mm, the thickness of 5.26±0.03 mm, disintegration time of 9.40±0.14 min, hardness of 15.46±0.84 kg/cm², weight uniformity of 506.74±2.86 mg, friability of 0.28±0.03%. Meanwhile, Pb and Cd metal contamination were not detected, microbial contamination with Total Plate Number gave (ALT) 4.20 x 10² colonies/g, Yeast Mold Number 1.18 x 10² colonies/g, and the water content of the tablet was 5.75%. The evaluation results also showed that formula III with a 100% Avicel PH 102 concentration had a relatively better disintegration time than others. Conclusion: Propolis extract microcapsule tablet has been success developed. The best formula was used 100% Avicel PH 102 concentration.

Original language	English
Pages (from-to)	47-52
Number of pages	6
Journal	International Journal of Applied Pharmaceutics
Volume	14
Issue number	Special Issue 1
DOIs	https://doi.org/10.22159/ijap.2022.v14s1.10
Publication status	Published - Jan 2022

Keywords

Avicel pH 102
Direct compress
Formulation
Microcapsules
Propolis
Quality parameters
Tablet

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10.22159/ijap.2022.v14s1.10

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title = "FORMULATION AND DETERMINATION OF QUALITY PARAMETERS OF PROPOLIS EXTRACT MICROCAPSULE TABLETS FROM TETRAGONULA SAPIENS",

abstract = "Objective: The study aimed to develop the dry powder of propolis microcapsules into tablet preparations. Methods: The tablet preparation was developed by direct compression method using Avicel PH 102 (filler-binder-disintegrant) with variations in Avicel PH 102 concentration of 50%, 75%, and 100%, respectively. Each of the tablets from these formulations was determined by the quality parameters of the preparation. Results: The results showed that the dry powder microcapsules had a yellow-brown powder physical form, flow time of 0.413g/second, compressibility of 18.56%, and fine powder was 80.04%. Out of the three formulae produced, formula III was the best with a tablet diameter of 11.11±0.01 mm, the thickness of 5.26±0.03 mm, disintegration time of 9.40±0.14 min, hardness of 15.46±0.84 kg/cm2, weight uniformity of 506.74±2.86 mg, friability of 0.28±0.03%. Meanwhile, Pb and Cd metal contamination were not detected, microbial contamination with Total Plate Number gave (ALT) 4.20 x 102 colonies/g, Yeast Mold Number 1.18 x 102 colonies/g, and the water content of the tablet was 5.75%. The evaluation results also showed that formula III with a 100% Avicel PH 102 concentration had a relatively better disintegration time than others. Conclusion: Propolis extract microcapsule tablet has been success developed. The best formula was used 100% Avicel PH 102 concentration.",

keywords = "Avicel pH 102, Direct compress, Formulation, Microcapsules, Propolis, Quality parameters, Tablet",

author = "Pratami, {Diah Kartika} and Deni Rahmat and Amalia, {Rizka Noor} and Heri Hermasnyah and Misri Gozan and Muhamad Sahlan",

note = "Funding Information: The authors would like to thank The Ministry of Education, Culture, and High Education of Republic of Indonesia for financial support through PPUPT Grant (NKB-233/UN2. RST/HKP.05.00/2021). Publisher Copyright: {\textcopyright} 2022 The Authors. Published by Innovare Academic Sciences Pvt Ltd.",

year = "2022",

month = jan,

doi = "10.22159/ijap.2022.v14s1.10",

language = "English",

volume = "14",

pages = "47--52",

journal = "International Journal of Applied Pharmaceutics",

issn = "0975-7058",

publisher = "International Journal of Applied Pharmaceutics",

number = "Special Issue 1",

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TY - JOUR

T1 - FORMULATION AND DETERMINATION OF QUALITY PARAMETERS OF PROPOLIS EXTRACT MICROCAPSULE TABLETS FROM TETRAGONULA SAPIENS

AU - Pratami, Diah Kartika

AU - Rahmat, Deni

AU - Amalia, Rizka Noor

AU - Hermasnyah, Heri

AU - Gozan, Misri

AU - Sahlan, Muhamad

N1 - Funding Information: The authors would like to thank The Ministry of Education, Culture, and High Education of Republic of Indonesia for financial support through PPUPT Grant (NKB-233/UN2. RST/HKP.05.00/2021). Publisher Copyright: © 2022 The Authors. Published by Innovare Academic Sciences Pvt Ltd.

PY - 2022/1

Y1 - 2022/1

N2 - Objective: The study aimed to develop the dry powder of propolis microcapsules into tablet preparations. Methods: The tablet preparation was developed by direct compression method using Avicel PH 102 (filler-binder-disintegrant) with variations in Avicel PH 102 concentration of 50%, 75%, and 100%, respectively. Each of the tablets from these formulations was determined by the quality parameters of the preparation. Results: The results showed that the dry powder microcapsules had a yellow-brown powder physical form, flow time of 0.413g/second, compressibility of 18.56%, and fine powder was 80.04%. Out of the three formulae produced, formula III was the best with a tablet diameter of 11.11±0.01 mm, the thickness of 5.26±0.03 mm, disintegration time of 9.40±0.14 min, hardness of 15.46±0.84 kg/cm2, weight uniformity of 506.74±2.86 mg, friability of 0.28±0.03%. Meanwhile, Pb and Cd metal contamination were not detected, microbial contamination with Total Plate Number gave (ALT) 4.20 x 102 colonies/g, Yeast Mold Number 1.18 x 102 colonies/g, and the water content of the tablet was 5.75%. The evaluation results also showed that formula III with a 100% Avicel PH 102 concentration had a relatively better disintegration time than others. Conclusion: Propolis extract microcapsule tablet has been success developed. The best formula was used 100% Avicel PH 102 concentration.

AB - Objective: The study aimed to develop the dry powder of propolis microcapsules into tablet preparations. Methods: The tablet preparation was developed by direct compression method using Avicel PH 102 (filler-binder-disintegrant) with variations in Avicel PH 102 concentration of 50%, 75%, and 100%, respectively. Each of the tablets from these formulations was determined by the quality parameters of the preparation. Results: The results showed that the dry powder microcapsules had a yellow-brown powder physical form, flow time of 0.413g/second, compressibility of 18.56%, and fine powder was 80.04%. Out of the three formulae produced, formula III was the best with a tablet diameter of 11.11±0.01 mm, the thickness of 5.26±0.03 mm, disintegration time of 9.40±0.14 min, hardness of 15.46±0.84 kg/cm2, weight uniformity of 506.74±2.86 mg, friability of 0.28±0.03%. Meanwhile, Pb and Cd metal contamination were not detected, microbial contamination with Total Plate Number gave (ALT) 4.20 x 102 colonies/g, Yeast Mold Number 1.18 x 102 colonies/g, and the water content of the tablet was 5.75%. The evaluation results also showed that formula III with a 100% Avicel PH 102 concentration had a relatively better disintegration time than others. Conclusion: Propolis extract microcapsule tablet has been success developed. The best formula was used 100% Avicel PH 102 concentration.

KW - Avicel pH 102

KW - Direct compress

KW - Formulation

KW - Microcapsules

KW - Propolis

KW - Quality parameters

KW - Tablet

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DO - 10.22159/ijap.2022.v14s1.10

M3 - Article

AN - SCOPUS:85126949677

SN - 0975-7058

VL - 14

SP - 47

EP - 52

JO - International Journal of Applied Pharmaceutics

JF - International Journal of Applied Pharmaceutics

IS - Special Issue 1

ER -

FORMULATION AND DETERMINATION OF QUALITY PARAMETERS OF PROPOLIS EXTRACT MICROCAPSULE TABLETS FROM TETRAGONULA SAPIENS

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Keywords

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