TY - JOUR
T1 - FORMULATION AND DETERMINATION OF QUALITY PARAMETERS OF PROPOLIS EXTRACT MICROCAPSULE TABLETS FROM TETRAGONULA SAPIENS
AU - Pratami, Diah Kartika
AU - Rahmat, Deni
AU - Amalia, Rizka Noor
AU - Hermasnyah, Heri
AU - Gozan, Misri
AU - Sahlan, Muhamad
N1 - Funding Information:
The authors would like to thank The Ministry of Education, Culture, and High Education of Republic of Indonesia for financial support through PPUPT Grant (NKB-233/UN2. RST/HKP.05.00/2021).
Publisher Copyright:
© 2022 The Authors. Published by Innovare Academic Sciences Pvt Ltd.
PY - 2022/1
Y1 - 2022/1
N2 - Objective: The study aimed to develop the dry powder of propolis microcapsules into tablet preparations. Methods: The tablet preparation was developed by direct compression method using Avicel PH 102 (filler-binder-disintegrant) with variations in Avicel PH 102 concentration of 50%, 75%, and 100%, respectively. Each of the tablets from these formulations was determined by the quality parameters of the preparation. Results: The results showed that the dry powder microcapsules had a yellow-brown powder physical form, flow time of 0.413g/second, compressibility of 18.56%, and fine powder was 80.04%. Out of the three formulae produced, formula III was the best with a tablet diameter of 11.11±0.01 mm, the thickness of 5.26±0.03 mm, disintegration time of 9.40±0.14 min, hardness of 15.46±0.84 kg/cm2, weight uniformity of 506.74±2.86 mg, friability of 0.28±0.03%. Meanwhile, Pb and Cd metal contamination were not detected, microbial contamination with Total Plate Number gave (ALT) 4.20 x 102 colonies/g, Yeast Mold Number 1.18 x 102 colonies/g, and the water content of the tablet was 5.75%. The evaluation results also showed that formula III with a 100% Avicel PH 102 concentration had a relatively better disintegration time than others. Conclusion: Propolis extract microcapsule tablet has been success developed. The best formula was used 100% Avicel PH 102 concentration.
AB - Objective: The study aimed to develop the dry powder of propolis microcapsules into tablet preparations. Methods: The tablet preparation was developed by direct compression method using Avicel PH 102 (filler-binder-disintegrant) with variations in Avicel PH 102 concentration of 50%, 75%, and 100%, respectively. Each of the tablets from these formulations was determined by the quality parameters of the preparation. Results: The results showed that the dry powder microcapsules had a yellow-brown powder physical form, flow time of 0.413g/second, compressibility of 18.56%, and fine powder was 80.04%. Out of the three formulae produced, formula III was the best with a tablet diameter of 11.11±0.01 mm, the thickness of 5.26±0.03 mm, disintegration time of 9.40±0.14 min, hardness of 15.46±0.84 kg/cm2, weight uniformity of 506.74±2.86 mg, friability of 0.28±0.03%. Meanwhile, Pb and Cd metal contamination were not detected, microbial contamination with Total Plate Number gave (ALT) 4.20 x 102 colonies/g, Yeast Mold Number 1.18 x 102 colonies/g, and the water content of the tablet was 5.75%. The evaluation results also showed that formula III with a 100% Avicel PH 102 concentration had a relatively better disintegration time than others. Conclusion: Propolis extract microcapsule tablet has been success developed. The best formula was used 100% Avicel PH 102 concentration.
KW - Avicel pH 102
KW - Direct compress
KW - Formulation
KW - Microcapsules
KW - Propolis
KW - Quality parameters
KW - Tablet
UR - http://www.scopus.com/inward/record.url?scp=85126949677&partnerID=8YFLogxK
U2 - 10.22159/ijap.2022.v14s1.10
DO - 10.22159/ijap.2022.v14s1.10
M3 - Article
AN - SCOPUS:85126949677
SN - 0975-7058
VL - 14
SP - 47
EP - 52
JO - International Journal of Applied Pharmaceutics
JF - International Journal of Applied Pharmaceutics
IS - Special Issue 1
ER -