TY - JOUR
T1 - Formulation and characterization of nanoemulgel mangosteen extract in virgin coconut oil for topical formulation
AU - Mulia, Kamarza
AU - Ramadhan, Rosalia M.A.
AU - Krisanti, Elsa Anisa
N1 - Publisher Copyright:
© The Authors, published by EDP Sciences, 2018.
PY - 2018/3/14
Y1 - 2018/3/14
N2 - A hydrogel of nanoemulsion system containing mangosteen extract of mangosteen rind was developed and characterized for the purpose of topical formulation. Mangostins, the bioactive in the extract, has been known to have biological activities such as antifungal, antibacterial, antioxidant, antiviral and antitumoral. Due to the hydrophobic nature of mangostins, they can not to be directly formulated into a gel. Oil-in-water nanoemulsions were formulated of virgin coconut oil (VCO) as the oil phase and mixed surfactant consisting of Tween 80 and Span 80, using the high-speed homogenization method. Nanoemulgel formed by mixing the nanoemulsion with aqueous solution of xanthan gum, and added phenoxyethanol as a preservative, was a homogeneous milky white gel. The stability test through accelerated centrifugation and freeze-thaw cycle showed that the nanoemulgel would be stable for at least one year. The nanoemulgel penetrated the skin layer up to 12 μg/cm2 or more than 95% of its total mangostin content, better than the skin penetration result of the nanoemulsion formulation. The present study revealed that VCO-mangostins nanoemulgel formulation is a prospective topical formulation.
AB - A hydrogel of nanoemulsion system containing mangosteen extract of mangosteen rind was developed and characterized for the purpose of topical formulation. Mangostins, the bioactive in the extract, has been known to have biological activities such as antifungal, antibacterial, antioxidant, antiviral and antitumoral. Due to the hydrophobic nature of mangostins, they can not to be directly formulated into a gel. Oil-in-water nanoemulsions were formulated of virgin coconut oil (VCO) as the oil phase and mixed surfactant consisting of Tween 80 and Span 80, using the high-speed homogenization method. Nanoemulgel formed by mixing the nanoemulsion with aqueous solution of xanthan gum, and added phenoxyethanol as a preservative, was a homogeneous milky white gel. The stability test through accelerated centrifugation and freeze-thaw cycle showed that the nanoemulgel would be stable for at least one year. The nanoemulgel penetrated the skin layer up to 12 μg/cm2 or more than 95% of its total mangostin content, better than the skin penetration result of the nanoemulsion formulation. The present study revealed that VCO-mangostins nanoemulgel formulation is a prospective topical formulation.
UR - http://www.scopus.com/inward/record.url?scp=85044398687&partnerID=8YFLogxK
U2 - 10.1051/matecconf/201815601013
DO - 10.1051/matecconf/201815601013
M3 - Conference article
AN - SCOPUS:85044398687
SN - 2261-236X
VL - 156
JO - MATEC Web of Conferences
JF - MATEC Web of Conferences
M1 - 01013
T2 - 24th Regional Symposium on Chemical Engineering, RSCE 2017
Y2 - 15 November 2017 through 16 November 2017
ER -