TY - JOUR
T1 - Formulation and characterization of bitter melon extract (Momordica charantia) loaded phytosomes
AU - Sasongko, Rhatih Eka
AU - Surini, Silvia
AU - Saputri, Fadlina Chany
N1 - Publisher Copyright:
© 2019 Phcogj.Com.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Objective: Phytosomes are a novel drug delivery system that offers better absorption and bioavailability for extract or phytoconstituents. The aim of this study was developing bitter melon extract load phytosomes with appropriate characteristics for transdermal delivery. Methods: Three formulas were developed, F1, F2 and F3 with weight ratios of extract and phosphatidylcholine were 1: 1, 1: 2 and 1: 3, respectively. Bitter melon fruit was extracted using a maceration method and the marker compounds were determined by high performance liquid chromatography (HPLC) method. Phytosomes were prepared using thin layer method and then characterized, in terms of morphology, particle size distribution, zeta potential and entrapment efficiency. Results: The results of pytosomes characterization reveals that the F3 was the optimal formula. It has a spherical shape, particle size (DV-mean) was 282.3 ± 16.4 nm, zeta potential value at -39.2 ± 0.14 mV and entrapment efficiency of 90.06 ± 1.07 %. Conclusion: Bitter melon extract loaded phytosomes with a weight ratio of extract and phosphatidylcholine 1:3 (F3) was selected as an optimal formula with appropriate characteristics for transdermal delivery.
AB - Objective: Phytosomes are a novel drug delivery system that offers better absorption and bioavailability for extract or phytoconstituents. The aim of this study was developing bitter melon extract load phytosomes with appropriate characteristics for transdermal delivery. Methods: Three formulas were developed, F1, F2 and F3 with weight ratios of extract and phosphatidylcholine were 1: 1, 1: 2 and 1: 3, respectively. Bitter melon fruit was extracted using a maceration method and the marker compounds were determined by high performance liquid chromatography (HPLC) method. Phytosomes were prepared using thin layer method and then characterized, in terms of morphology, particle size distribution, zeta potential and entrapment efficiency. Results: The results of pytosomes characterization reveals that the F3 was the optimal formula. It has a spherical shape, particle size (DV-mean) was 282.3 ± 16.4 nm, zeta potential value at -39.2 ± 0.14 mV and entrapment efficiency of 90.06 ± 1.07 %. Conclusion: Bitter melon extract loaded phytosomes with a weight ratio of extract and phosphatidylcholine 1:3 (F3) was selected as an optimal formula with appropriate characteristics for transdermal delivery.
KW - Bitter melon
KW - Momordica charantia
KW - Phytosomes
KW - Thin layer method
KW - Transdermal delivery
UR - http://www.scopus.com/inward/record.url?scp=85074490417&partnerID=8YFLogxK
U2 - 10.5530/pj.2019.11.192
DO - 10.5530/pj.2019.11.192
M3 - Article
AN - SCOPUS:85074490417
SN - 0975-3575
VL - 11
SP - 1235
EP - 1241
JO - Pharmacognosy Journal
JF - Pharmacognosy Journal
IS - 6
ER -