Formulasi Emulgel yang Mengandung Ekstrak Etanol Daun Binahong (Anredera cordifolia (Ten.) Steenis) dan Uji Aktivitasnya terhadap Propionibacterium acnes secara In Vitro

Tri Nofi Yani, Effionora Anwar, Fadlina Chany Saputri

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Binahong (Anredera cordifolia (Ten.) Steenis) leaves have been known to have antibacterial activity but the activity against Propionibacterium acnes as one of the bacteria that play a role in acne’s pathogenesis is still unknown. Binahong leaves ethanolic extract containing 1,28% of ursolic acid in this study were tested by in vitro against Propionibacterium acnes giving result minimum bactericidal concentration of 0,05%. Emulgel of binahong leaves ethanolic extract in this study had physical stability for 12 weeks. Inhibition zone of binahong leaves ethanolic extract emulgel is larger than clindamycin phosphate 1,2% against Propionibacterium acnes, which is in formula 1 (extract equivalen with MIC 0,05%) is 19,67±1,25 mm and formula 2 (extract equivalen double MIC 0,05%) is
20,67±0,47 mm, while inhibition zone of clindamycin phosphate 1,2% is 16,3±0,47 mm
Original languageIndonesian
JournalJurnal Kefarmasian Indonesia
Issue number2
Publication statusPublished - 2016

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