Fluconazole and itraconazole susceptibility pattern in monofungal and multifungal infection in cipto mangunkusumo general hospital: Cross-sectional study

Adrian Reynaldo Sudirman, Parida Oktama Putri, Andrian Wiraguna, Ridhawati

Research output: Contribution to journalArticle

Abstract

Introduction: Fungal infection becomes the highest prevalence diseases in tropical countries. The drug of choice of monofungal infection is Fluconazole. There is no therapeutic suggestion for multifungal infections. This study aims to give recommendation regarding the drugs of choice in monofungal and multifungal infections based on the drug susceptibility analysis. Method: Cross-sectional Study was applied to analyse the susceptibility pattern of Fluconazole and Itraconazole administration. The data selection was obtained from medical record of Parasitology Department at Cipto Mangunkusumo General Hospital. The sample selection was performed with total random sampling method. The data was processed and analysed using Chi-square method. Result: From 290 subjects, 154 subjects have monofungal infections while others have multifungal infections. Analytical study using Chi-square Test indicated significant association (p =0.003) between Fluconazole susceptibility and fungal infections (0.280, 95%CI: 0.117–0.670). There is no significant association (p = 0.601) between Itraconazole susceptibility pattern and fungal infection. Conclusion: The consistency of Fluconazole performance has been proofed by drug susceptibility test performed in this study. Moreover, it has effective pharmacokinetic profile and well tolerated in patients. Itraconazole has same efficacy, but less tolerated and have more side effects than Fluconazole. Therefore, we recommended Fluconazole as drug of choice in monofungal and multifungal infection.

Original languageEnglish
Pages (from-to)6939-6942
Number of pages4
JournalAdvanced Science Letters
Volume23
Issue number7
DOIs
Publication statusPublished - 1 Jul 2017

Keywords

  • Fluconazole
  • Itraconazole
  • Monofungal
  • Multifungal
  • Susceptibility Test

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