Flow focusing microfluidics or stem cell dual layers droplet microencapsulation

Shabrina Fadhilah; Yudan Whulanza

doi:10.1063/5.0047168

Flow focusing microfluidics or stem cell dual layers droplet microencapsulation

Shabrina Fadhilah, Yudan Whulanza

Department of Mechanical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

2 Citations (Scopus)

Abstract

Stem cell therapy is renowned as one of therapeutic treatments for injury, cancer, or other health issues in regard to tissue regeneration. This method needs special approach because stem cell must be retained in a specific environment that can control its viability and advantages. Microencapsulation is one of them. This study is aimed to propose stem cell microencapsulation using microfluidics chip to enable size control of the encapsulated cells. Microfluidics is chosen because it can control the size of the encapsulated cell. The stem cell will be encapsulated in dual layers to enhance its protection in the human body, in which the first layer is alginate + Calcium and the second layer is PEG (polyethylene glycol). However, this paper will focus on the simulation of cell microencapsulation in flow focusing microfluidics channel since flow focusing microfluidics channel has been proven to generate desired microfluidics droplet as encapsulated cell. Using computational fluids dynamics software, the microfluidics droplet is processed by volume of fluids method with multiphase calculation. The primary phase is water and the second phase is oil. The CFD simulation shows that desired droplet is successfully generated. Therefore, this paper can be the first step of the proposed study in the stem cell dual layers microencapsulation.

Original language	English
Title of host publication	5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
Subtitle of host publication	Proceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020
Editors	Kenny Lischer, Sugeng Supriadi, Siti Fauziyah Rahman, Yudan Whulanza
Publisher	American Institute of Physics Inc.
ISBN (Electronic)	9780735440869
DOIs	https://doi.org/10.1063/5.0047168
Publication status	Published - 23 Mar 2021
Event	5th International Symposium of Biomedical Engineering, ISBE 2020 - Depok, Virtual, Indonesia Duration: 28 Jul 2020 → 29 Jul 2020

Publication series

Name	AIP Conference Proceedings
Volume	2344
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	5th International Symposium of Biomedical Engineering, ISBE 2020
Country/Territory	Indonesia
City	Depok, Virtual
Period	28/07/20 → 29/07/20

Keywords

droplet
microfluidics
stem cell

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1063/5.0047168

Cite this

Fadhilah, S., & Whulanza, Y. (2021). Flow focusing microfluidics or stem cell dual layers droplet microencapsulation. In K. Lischer, S. Supriadi, S. F. Rahman, & Y. Whulanza (Eds.), 5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020 Article 040014 (AIP Conference Proceedings; Vol. 2344). American Institute of Physics Inc.. https://doi.org/10.1063/5.0047168

Fadhilah, Shabrina ; Whulanza, Yudan. / Flow focusing microfluidics or stem cell dual layers droplet microencapsulation. 5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020. editor / Kenny Lischer ; Sugeng Supriadi ; Siti Fauziyah Rahman ; Yudan Whulanza. American Institute of Physics Inc., 2021. (AIP Conference Proceedings).

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abstract = "Stem cell therapy is renowned as one of therapeutic treatments for injury, cancer, or other health issues in regard to tissue regeneration. This method needs special approach because stem cell must be retained in a specific environment that can control its viability and advantages. Microencapsulation is one of them. This study is aimed to propose stem cell microencapsulation using microfluidics chip to enable size control of the encapsulated cells. Microfluidics is chosen because it can control the size of the encapsulated cell. The stem cell will be encapsulated in dual layers to enhance its protection in the human body, in which the first layer is alginate + Calcium and the second layer is PEG (polyethylene glycol). However, this paper will focus on the simulation of cell microencapsulation in flow focusing microfluidics channel since flow focusing microfluidics channel has been proven to generate desired microfluidics droplet as encapsulated cell. Using computational fluids dynamics software, the microfluidics droplet is processed by volume of fluids method with multiphase calculation. The primary phase is water and the second phase is oil. The CFD simulation shows that desired droplet is successfully generated. Therefore, this paper can be the first step of the proposed study in the stem cell dual layers microencapsulation.",

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author = "Shabrina Fadhilah and Yudan Whulanza",

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Fadhilah, S & Whulanza, Y 2021, Flow focusing microfluidics or stem cell dual layers droplet microencapsulation. in K Lischer, S Supriadi, SF Rahman & Y Whulanza (eds), 5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020., 040014, AIP Conference Proceedings, vol. 2344, American Institute of Physics Inc., 5th International Symposium of Biomedical Engineering, ISBE 2020, Depok, Virtual, Indonesia, 28/07/20. https://doi.org/10.1063/5.0047168

Flow focusing microfluidics or stem cell dual layers droplet microencapsulation. / Fadhilah, Shabrina; Whulanza, Yudan.
5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020. ed. / Kenny Lischer; Sugeng Supriadi; Siti Fauziyah Rahman; Yudan Whulanza. American Institute of Physics Inc., 2021. 040014 (AIP Conference Proceedings; Vol. 2344).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Flow focusing microfluidics or stem cell dual layers droplet microencapsulation

AU - Fadhilah, Shabrina

AU - Whulanza, Yudan

PY - 2021/3/23

Y1 - 2021/3/23

N2 - Stem cell therapy is renowned as one of therapeutic treatments for injury, cancer, or other health issues in regard to tissue regeneration. This method needs special approach because stem cell must be retained in a specific environment that can control its viability and advantages. Microencapsulation is one of them. This study is aimed to propose stem cell microencapsulation using microfluidics chip to enable size control of the encapsulated cells. Microfluidics is chosen because it can control the size of the encapsulated cell. The stem cell will be encapsulated in dual layers to enhance its protection in the human body, in which the first layer is alginate + Calcium and the second layer is PEG (polyethylene glycol). However, this paper will focus on the simulation of cell microencapsulation in flow focusing microfluidics channel since flow focusing microfluidics channel has been proven to generate desired microfluidics droplet as encapsulated cell. Using computational fluids dynamics software, the microfluidics droplet is processed by volume of fluids method with multiphase calculation. The primary phase is water and the second phase is oil. The CFD simulation shows that desired droplet is successfully generated. Therefore, this paper can be the first step of the proposed study in the stem cell dual layers microencapsulation.

AB - Stem cell therapy is renowned as one of therapeutic treatments for injury, cancer, or other health issues in regard to tissue regeneration. This method needs special approach because stem cell must be retained in a specific environment that can control its viability and advantages. Microencapsulation is one of them. This study is aimed to propose stem cell microencapsulation using microfluidics chip to enable size control of the encapsulated cells. Microfluidics is chosen because it can control the size of the encapsulated cell. The stem cell will be encapsulated in dual layers to enhance its protection in the human body, in which the first layer is alginate + Calcium and the second layer is PEG (polyethylene glycol). However, this paper will focus on the simulation of cell microencapsulation in flow focusing microfluidics channel since flow focusing microfluidics channel has been proven to generate desired microfluidics droplet as encapsulated cell. Using computational fluids dynamics software, the microfluidics droplet is processed by volume of fluids method with multiphase calculation. The primary phase is water and the second phase is oil. The CFD simulation shows that desired droplet is successfully generated. Therefore, this paper can be the first step of the proposed study in the stem cell dual layers microencapsulation.

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KW - stem cell

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AN - SCOPUS:85103498859

T3 - AIP Conference Proceedings

BT - 5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices

A2 - Lischer, Kenny

A2 - Supriadi, Sugeng

A2 - Rahman, Siti Fauziyah

A2 - Whulanza, Yudan

PB - American Institute of Physics Inc.

T2 - 5th International Symposium of Biomedical Engineering, ISBE 2020

Y2 - 28 July 2020 through 29 July 2020

ER -

Fadhilah S, Whulanza Y. Flow focusing microfluidics or stem cell dual layers droplet microencapsulation. In Lischer K, Supriadi S, Rahman SF, Whulanza Y, editors, 5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020. American Institute of Physics Inc. 2021. 040014. (AIP Conference Proceedings). doi: 10.1063/5.0047168

Flow focusing microfluidics or stem cell dual layers droplet microencapsulation

Abstract

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Keywords

UN SDGs

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