Flow focusing microfluidics or stem cell dual layers droplet microencapsulation

Shabrina Fadhilah, Yudan Whulanza

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Stem cell therapy is renowned as one of therapeutic treatments for injury, cancer, or other health issues in regard to tissue regeneration. This method needs special approach because stem cell must be retained in a specific environment that can control its viability and advantages. Microencapsulation is one of them. This study is aimed to propose stem cell microencapsulation using microfluidics chip to enable size control of the encapsulated cells. Microfluidics is chosen because it can control the size of the encapsulated cell. The stem cell will be encapsulated in dual layers to enhance its protection in the human body, in which the first layer is alginate + Calcium and the second layer is PEG (polyethylene glycol). However, this paper will focus on the simulation of cell microencapsulation in flow focusing microfluidics channel since flow focusing microfluidics channel has been proven to generate desired microfluidics droplet as encapsulated cell. Using computational fluids dynamics software, the microfluidics droplet is processed by volume of fluids method with multiphase calculation. The primary phase is water and the second phase is oil. The CFD simulation shows that desired droplet is successfully generated. Therefore, this paper can be the first step of the proposed study in the stem cell dual layers microencapsulation.

Original languageEnglish
Title of host publication5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
Subtitle of host publicationProceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020
EditorsKenny Lischer, Sugeng Supriadi, Siti Fauziyah Rahman, Yudan Whulanza
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735440869
DOIs
Publication statusPublished - 23 Mar 2021
Event5th International Symposium of Biomedical Engineering, ISBE 2020 - Depok, Virtual, Indonesia
Duration: 28 Jul 202029 Jul 2020

Publication series

NameAIP Conference Proceedings
Volume2344
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference5th International Symposium of Biomedical Engineering, ISBE 2020
CountryIndonesia
CityDepok, Virtual
Period28/07/2029/07/20

Keywords

  • droplet
  • microfluidics
  • stem cell

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