Fibrinogen and LDL Influence on Blood Viscosity and Outcome of Acute Ischemic Stroke Patients in Indonesia

Al Rasyid; Salim Harris; Mohammad Kurniawan; Rakhmad Hidayat; Taufik Mesiano

doi:10.1177/0972753119900630

Fibrinogen and LDL Influence on Blood Viscosity and Outcome of Acute Ischemic Stroke Patients in Indonesia

Al Rasyid, Salim Harris, Mohammad Kurniawan, Rakhmad Hidayat, Taufik Mesiano

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Background: To assess the role of risk factors of metabolic syndrome on blood viscosity and the prognosis of acute ischemic stroke in Indonesia based on the National Institute of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS). Methods: This study included 135 patients with acute ischemic stroke. Patients underwent measurements of viscosity and risk factor assessment. Analysis was performed to assess the role of these risk factors for blood viscosity and outcomes of acute ischemic stroke with NIHSS and mRS as indicators. NIHSS was assessed at <3 days after onset and 7 days after onset, while mRS was assessed 1 month post treatment. Bivariate analysis was performed using chi-square test, and variables with p < 0.25 were further analyzed in multivariate analysis using logistic regression. Results: Factors affecting blood viscosity are fibrinogen, low-density lipoprotein (LDL), and hematocrit. Factors affecting NIHSS and mRS are fibrinogen and LDL. Conclusion: Fibrinogen and LDL affect the viscosity of blood and outcomes in acute ischemic stroke patients, so it is necessary to treat in the primary and secondary prevention of ischemic stroke.

Original language	English
Pages (from-to)	30-34
Number of pages	5
Journal	Annals of Neurosciences
Volume	26
Issue number	3-4
DOIs	https://doi.org/10.1177/0972753119900630
Publication status	Published - 1 Jul 2019

Keywords

Acute ischemic stroke
blood viscosity
fibrinogen
LDL

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title = "Fibrinogen and LDL Influence on Blood Viscosity and Outcome of Acute Ischemic Stroke Patients in Indonesia",

abstract = "Background: To assess the role of risk factors of metabolic syndrome on blood viscosity and the prognosis of acute ischemic stroke in Indonesia based on the National Institute of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS). Methods: This study included 135 patients with acute ischemic stroke. Patients underwent measurements of viscosity and risk factor assessment. Analysis was performed to assess the role of these risk factors for blood viscosity and outcomes of acute ischemic stroke with NIHSS and mRS as indicators. NIHSS was assessed at <3 days after onset and 7 days after onset, while mRS was assessed 1 month post treatment. Bivariate analysis was performed using chi-square test, and variables with p < 0.25 were further analyzed in multivariate analysis using logistic regression. Results: Factors affecting blood viscosity are fibrinogen, low-density lipoprotein (LDL), and hematocrit. Factors affecting NIHSS and mRS are fibrinogen and LDL. Conclusion: Fibrinogen and LDL affect the viscosity of blood and outcomes in acute ischemic stroke patients, so it is necessary to treat in the primary and secondary prevention of ischemic stroke.",

keywords = "Acute ischemic stroke, blood viscosity, fibrinogen, LDL",

author = "Al Rasyid and Salim Harris and Mohammad Kurniawan and Rakhmad Hidayat and Taufik Mesiano",

note = "Funding Information: We would like to thank Cipto Mangunkusumo Hospital and Department of Neurology Universitas Indonesia for facilitating this research. We would also like to thank Fatmawati Hospital, Prikasih Jakarta Hospital, and Bhakti Yuda Hospital for allowing us to collect the required data for this research. Publisher Copyright: {\textcopyright} 2020 Indian Academy of Neurosciences (IAN).",

year = "2019",

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doi = "10.1177/0972753119900630",

language = "English",

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pages = "30--34",

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TY - JOUR

T1 - Fibrinogen and LDL Influence on Blood Viscosity and Outcome of Acute Ischemic Stroke Patients in Indonesia

AU - Rasyid, Al

AU - Harris, Salim

AU - Kurniawan, Mohammad

AU - Hidayat, Rakhmad

AU - Mesiano, Taufik

N1 - Funding Information: We would like to thank Cipto Mangunkusumo Hospital and Department of Neurology Universitas Indonesia for facilitating this research. We would also like to thank Fatmawati Hospital, Prikasih Jakarta Hospital, and Bhakti Yuda Hospital for allowing us to collect the required data for this research. Publisher Copyright: © 2020 Indian Academy of Neurosciences (IAN).

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Background: To assess the role of risk factors of metabolic syndrome on blood viscosity and the prognosis of acute ischemic stroke in Indonesia based on the National Institute of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS). Methods: This study included 135 patients with acute ischemic stroke. Patients underwent measurements of viscosity and risk factor assessment. Analysis was performed to assess the role of these risk factors for blood viscosity and outcomes of acute ischemic stroke with NIHSS and mRS as indicators. NIHSS was assessed at <3 days after onset and 7 days after onset, while mRS was assessed 1 month post treatment. Bivariate analysis was performed using chi-square test, and variables with p < 0.25 were further analyzed in multivariate analysis using logistic regression. Results: Factors affecting blood viscosity are fibrinogen, low-density lipoprotein (LDL), and hematocrit. Factors affecting NIHSS and mRS are fibrinogen and LDL. Conclusion: Fibrinogen and LDL affect the viscosity of blood and outcomes in acute ischemic stroke patients, so it is necessary to treat in the primary and secondary prevention of ischemic stroke.

AB - Background: To assess the role of risk factors of metabolic syndrome on blood viscosity and the prognosis of acute ischemic stroke in Indonesia based on the National Institute of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS). Methods: This study included 135 patients with acute ischemic stroke. Patients underwent measurements of viscosity and risk factor assessment. Analysis was performed to assess the role of these risk factors for blood viscosity and outcomes of acute ischemic stroke with NIHSS and mRS as indicators. NIHSS was assessed at <3 days after onset and 7 days after onset, while mRS was assessed 1 month post treatment. Bivariate analysis was performed using chi-square test, and variables with p < 0.25 were further analyzed in multivariate analysis using logistic regression. Results: Factors affecting blood viscosity are fibrinogen, low-density lipoprotein (LDL), and hematocrit. Factors affecting NIHSS and mRS are fibrinogen and LDL. Conclusion: Fibrinogen and LDL affect the viscosity of blood and outcomes in acute ischemic stroke patients, so it is necessary to treat in the primary and secondary prevention of ischemic stroke.

KW - Acute ischemic stroke

KW - blood viscosity

KW - fibrinogen

KW - LDL

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DO - 10.1177/0972753119900630

M3 - Article

AN - SCOPUS:85089185753

SN - 0972-7531

VL - 26

SP - 30

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JO - Annals of Neurosciences

JF - Annals of Neurosciences

IS - 3-4

ER -

Fibrinogen and LDL Influence on Blood Viscosity and Outcome of Acute Ischemic Stroke Patients in Indonesia

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