Fe3O4/eggshells composite as green catalyst for Hantzsch condensation in acridine synthesis

A. H. Cahyana, E. Saepudin, M. Surya, B. Ardiansah

Research output: Contribution to journalConference articlepeer-review

1 Citation (Scopus)


Acridine derivatives are a class of nitrogen heterocycles which have broad spectrum of important biological properties and pharmaceutical applications. Low-cost eggshells waste material was used as source of CaCO3 to modified magnetic Fe3O4 particles prepared from co-precipitation to serve as reusable heterogeneous catalyst. The synthesized eggshells based catalyst is characterized by X-ray diffraction (XRD) and TEM studies. The activity of the catalyst has been investigated in Hantzsch condensation reaction with good yields and simple work-up procedure. The synthesis of acridine derivative was achieved through a one-pot, three-component condensation of dimedone, aryl amine and aryl aldehydes utilizing Fe3O4/eggshells composite as catalyst under mild conditions. Maximum yield obtained is 91.3% with reflux condition, amount of catalyst 0.0254 g, and 1.5 h reaction time. Catalyst used can be separated magnetically and can be reused up to three times without significant decrease of yield. The synthesized compound was characterized using IR, UV-Vis and LC-MS.

Original languageEnglish
Article number012054
JournalIOP Conference Series: Materials Science and Engineering
Issue number1
Publication statusPublished - 22 Feb 2019
Event2nd International Conference on Current Progress in Functional Materials 2017, ISCPFM 2017 - Bali, Indonesia
Duration: 8 Nov 20179 Nov 2017


  • acridine
  • Fe3O4/eggshell
  • Hantzsch condensation


Dive into the research topics of 'Fe3O4/eggshells composite as green catalyst for Hantzsch condensation in acridine synthesis'. Together they form a unique fingerprint.

Cite this