TY - JOUR
T1 - Fas ligand (FasL) in association with Tumor-Infiltrating Lymphocytes (TILs) in early stage cervical cancer
AU - Anggraeni, Tricia Dewi
AU - Rustamadji, Primariadewi
AU - Aziz, M. Farid
N1 - Funding Information:
The study was greatly supported by the Division of Gynecologic Oncology -Department of Obstetrics and Gynecology, and the Department of Anatomic Pathology, Faculty of Medicine Universitas Indonesia -Cipto Mangunkusumo Hospital (CMH).
Publisher Copyright:
© 2020, Asian Pacific Organization for Cancer Prevention.
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Objective: To date, little is known about the roles of FasL and TILs in cervical cancer. This study aims to determine the correlation between FasL expression and TILs presence in cervical cancer. Methods: In this study, we analysed the FasL and TIL presence in 32 squamous cell carcinoma or adenocarcinoma that were obtained from early stage (≤ IIA2) cervical cancer patients using immunohistochemistry. The level of FasL and TIL was assessed qualitatively, and then quantified with the H-Score system. Results: Most of the patients were between 30 to 50 years old (59,4%), and had never taken pap smear examination before (96,9%). Based on the Pearson analysis of FasL and TIL presence, we found that FasL was inversely correlated with CD45 or TIL number when the level of FasL is above 140 and the CD45 is below 160. Based on Chi-Square test of FasL and TIL classification, there was a nine-fold odds ratio (OR) of lower TILs classification in high expression of FasL classification (OR 9, p=0.01). Conclusion: An inverse correlation between FasL expression and TILs level, that might indicate FasL-induced TILs apoptosis in tumor tissue, was observed. The strong inverse correlation between FasL and TILs presence showed some insight about the interactions between cancer cells and its surroundings inside of the cervical cancer tissue. This might also be further developed to tailor a prognostic marker that can predict the outcome of therapy in patients, not only in cervical cancer, but generally in all cancer.
AB - Objective: To date, little is known about the roles of FasL and TILs in cervical cancer. This study aims to determine the correlation between FasL expression and TILs presence in cervical cancer. Methods: In this study, we analysed the FasL and TIL presence in 32 squamous cell carcinoma or adenocarcinoma that were obtained from early stage (≤ IIA2) cervical cancer patients using immunohistochemistry. The level of FasL and TIL was assessed qualitatively, and then quantified with the H-Score system. Results: Most of the patients were between 30 to 50 years old (59,4%), and had never taken pap smear examination before (96,9%). Based on the Pearson analysis of FasL and TIL presence, we found that FasL was inversely correlated with CD45 or TIL number when the level of FasL is above 140 and the CD45 is below 160. Based on Chi-Square test of FasL and TIL classification, there was a nine-fold odds ratio (OR) of lower TILs classification in high expression of FasL classification (OR 9, p=0.01). Conclusion: An inverse correlation between FasL expression and TILs level, that might indicate FasL-induced TILs apoptosis in tumor tissue, was observed. The strong inverse correlation between FasL and TILs presence showed some insight about the interactions between cancer cells and its surroundings inside of the cervical cancer tissue. This might also be further developed to tailor a prognostic marker that can predict the outcome of therapy in patients, not only in cervical cancer, but generally in all cancer.
KW - Apoptosis
KW - Cervical cancer
KW - FasL
KW - TIL
UR - http://www.scopus.com/inward/record.url?scp=85082514884&partnerID=8YFLogxK
U2 - 10.31557/APJCP.2020.21.3.831
DO - 10.31557/APJCP.2020.21.3.831
M3 - Article
C2 - 32212814
AN - SCOPUS:85082514884
SN - 1513-7368
VL - 21
SP - 831
EP - 835
JO - Asian Pacific Journal of Cancer Prevention
JF - Asian Pacific Journal of Cancer Prevention
IS - 3
ER -
