Education has shifted towards the online system over the past year due to the coronavirus disease (COVID-19) outbreak. The purpose of this study is to explore and analyze Student-Centered E-Learning Environment (SCELE) as the Moodle learning system fully utilized by the Faculty of Computer Science in Universitas Indonesia for the learning process during the pandemic. A conceptual model was proposed by incorporating the Information System Success Model and the Technology Acceptance Model with the addition of interaction factors. This model was built to assess the factors contributing to influence the success of the e-learning system. One hundred active students from the faculty participated in the survey, and the data analysis was conducted with the Partial Least Squares Structural Equation Modeling (PLS-SEM) approach. Through hypothesis analysis and extended discussion, this research's findings suggested the quality of information and system as the factors that hold significant roles in the success of SCELE as an online learning system, along with the interaction mediated by perceived usefulness.