@article{9ca923d73c904fcc9b56dcd99b611ef9,
title = "Factors Associated with Dysplastic Changes in Sinonasal Inverted Papilloma: Study of Tumor Infiltrating Lymphocytes (TILs) FOXP3, CD4, CD8, and expression of p53",
abstract = "Objective: This study examine FOXP3, CD4, CD8 and p53 expression in the transformation of the Sinonasal Inverted Papilloma (SIP) malignancy into sinonasal carcinoma. Materials and Methods: This study used a crosssectional approach. The research sample from thirty-six paraffin block preparations with the diagnosis of SIP. Then, immunohistochemical staining was performed using FOXP3 mouse monoclonal antibody (236A/E7), CD8 rabbit monoclonal antibody (CD8/1179R), CD4 mouse monoclonal antibody (4B12) and p53 rabbit monoclonal antibody. Results: There was a significant difference between Foxp3 expression in SIP without dysplasia and SIP with dysplasia (p= 0.013). There was no significant difference between the expression of CD4 and CD8 in the two groups with p-values 0.1 and 0.062, respectively. The mean percentage of positive p53 expression in SIP without dysplasia was 0.45+0.63 and in the SIP with dysplasia 29.31+38.96. There was a significant difference between the two groups (p<0.001). Conclusion: FOXP3 and p53 were overexpressed in SIP with malignant transformation. FOXP3 together with p53 status is associated with dysplastic changed in the SIP. FOXP3 and p53 status could be potential biomarker of malignant transformation in sinonasal inverted papilloma.",
keywords = "Cd4, Cd8, Dysplastic changes, Foxp3, Inverted papilloma, P53, Sinonasal papilloma",
author = "Lisnawati Rachmadi and Susanto, {Yayi Dwina Billianti} and Manatar, {Amelia Fossetta} and David Sitinjak",
note = "Funding Information: Anatomical Pathology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital. This research was funded by The Directorate of Research and Community Service – Ministry of Research, Technology and Higher Education of the Republic of Indonesia grant for Higher Education Basic Research Program year 2021 (Grant No.: 111). The grant supported study design; collection, analysis and interpretation of data; report writing; and publication funding. No potential competing interest is disclosed in this study. Funding Information: We thank all staff members of the Department Anatomical Pathology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital. This research was funded by The Directorate of Research and Community Service – Ministry of Research, Technology and Higher Education of the Republic of Indonesia grant for Higher Education Basic Research Program year 2021 (Grant No.: 111). The grant supported study design; collection, analysis and interpretation of data; report writing; and publication funding. No potential competing interest is disclosed in this study. Publisher Copyright: {\textcopyright} This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License.",
year = "2022",
doi = "10.31557/APJCP.2022.23.9.3223",
language = "English",
volume = "23",
pages = "3223--3227",
journal = "Asian Pacific Journal of Cancer Prevention",
issn = "1513-7368",
publisher = "Asian Pacific Organization for Cancer Prevention",
number = "9",
}