Factors Associated with Dysplastic Changes in Sinonasal Inverted Papilloma: Study of Tumor Infiltrating Lymphocytes (TILs) FOXP3, CD4, CD8, and expression of p53

Lisnawati Rachmadi, Yayi Dwina Billianti Susanto, Amelia Fossetta Manatar, David Sitinjak

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: This study examine FOXP3, CD4, CD8 and p53 expression in the transformation of the Sinonasal Inverted Papilloma (SIP) malignancy into sinonasal carcinoma. Materials and Methods: This study used a crosssectional approach. The research sample from thirty-six paraffin block preparations with the diagnosis of SIP. Then, immunohistochemical staining was performed using FOXP3 mouse monoclonal antibody (236A/E7), CD8 rabbit monoclonal antibody (CD8/1179R), CD4 mouse monoclonal antibody (4B12) and p53 rabbit monoclonal antibody. Results: There was a significant difference between Foxp3 expression in SIP without dysplasia and SIP with dysplasia (p= 0.013). There was no significant difference between the expression of CD4 and CD8 in the two groups with p-values 0.1 and 0.062, respectively. The mean percentage of positive p53 expression in SIP without dysplasia was 0.45+0.63 and in the SIP with dysplasia 29.31+38.96. There was a significant difference between the two groups (p<0.001). Conclusion: FOXP3 and p53 were overexpressed in SIP with malignant transformation. FOXP3 together with p53 status is associated with dysplastic changed in the SIP. FOXP3 and p53 status could be potential biomarker of malignant transformation in sinonasal inverted papilloma.

Original languageEnglish
Pages (from-to)3223-3227
Number of pages5
JournalAsian Pacific Journal of Cancer Prevention
Volume23
Issue number9
DOIs
Publication statusPublished - 2022

Keywords

  • Cd4
  • Cd8
  • Dysplastic changes
  • Foxp3
  • Inverted papilloma
  • P53
  • Sinonasal papilloma

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